PestiGon Combo 50 mg / 60 mg Spot-on Solution for Cats and Ferrets
Active ingredients: (S)-Methoprene, Fipronil
Form
Spot-on
Species
Manufacturer
Norbrook Laboratories Limited
VMD MA No.
02000/4417
What it's used for
In cats: To be used against infestations with fleas, alone or in association with ticks and/or biting lice. •Ctenocephalides infestations with adult fleas...
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Paying less for (S)-Methoprene + Fipronil
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1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
PestiGon Combo 50 mg / 60 mg Spot-on Solution for Cats and Ferrets — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
•Ctenocephalides
infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas
for six weeks after application.
•Ixodes ricinus
sanguineus
against ticks (based on experimental data).
•Felicola subrostratus).
The product can be used as part of a treatment strategy for the control of Flea Allergy
Dermatitis (FAD).
Revised: April 2022
AN: 01183/2021 & 01185/2021
In ferrets:
To be used against infestations with fleas, alone or in association with ticks.
•Ctenocephalides
infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.
•Ixodes ricinus
efficacy for 4 weeks against ticks (based on experimental data).
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of
5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60
mg for (S)-methoprene per ferret.
The minimum treatment interval is 4 weeks.
Route of administration: External use only, spot-on use.
Only remove pipette from sachet immediately prior to use.
Method of Administration:
Remove the pipette from the outer sachet using scissors or fold along diagonal line to
expose nick; tear back at nick.
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Twist or snap back the tip.
Part the coat on the back of the animal at the base of the neck in front of the shoulder
blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the
pipette several times to empty its contents completely and directly onto the skin in
one spot.
Revised: April 2022
AN: 01183/2021 & 01185/2021
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
8 weeks old and/or weighing less than 1 kg. The product should not be used on
ferrets less than 6 months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse drug reactions with even mortality could occur.
In absence of studies, the use of the product is not recommended in non-target
species.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair loss
have been reported after use. Excessive salivation, reversible nervous signs (increased
sensitivity to stimulation, depression, other nervous signs) or vomiting have also been
observed after use.
The frequency of adverse reactions is defined using the following convention:
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier.
Special precautions for use in animals
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in cats
and ferrets are available. However, based on information available for dogs
shampooed as from 2 days after application of the product, it is not recommended to
bath animals within 2 days after application of the product.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal’s basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
Revised: April 2022
AN: 01183/2021 & 01185/2021
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided. Do not smoke,
drink or eat during the application. In case of accidental eye contact, immediately and
thoroughly rinse the eyes with clean water. If eye irritation persists seek medical
advice and show the package leaflet or the label to the physician. If contact with the
skin occurs, wash hands with soap and water.
People with a known hypersensitivity to insecticides or alcohol should avoid contact
with the veterinary medicinal product.
Wash hands after use.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product. In case of
accidental ingestion of product, seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Other precautions
The alcohol carrier may have adverse effects on painted, varnished or other household
surfaces or furnishings.
This veterinary medicinal product does not require any special temperature storage
conditions.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing (S)-Methoprene
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Bob Martin Clear Plus 134 mg/ 120.6 mg Spot-on Solution for Medium Dogs
AVM-GSLPets Choice Limited
Bob Martin Clear Plus 134 mg/ 120.6 mg Spot-on Solution for Medium Dogs
AVM-GSLPets Choice Healthcare Limited
Bob Martin Clear Plus 268 mg/ 241.2 mg Spot-on Solution for Large Dogs
AVM-GSLPets Choice Limited
Bob Martin Clear Plus 268 mg/ 241.2 mg Spot-on Solution for Large Dogs
AVM-GSLPets Choice Healthcare Limited
Bob Martin Clear Plus 402 mg/ 361.8 mg Spot-on Solution for Extra Large Dogs
AVM-GSLPets Choice Limited
Bob Martin Clear Plus 402 mg/ 361.8 mg Spot-on Solution for Extra Large Dogs
AVM-GSLPets Choice Healthcare Limited
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