Skip to content
POM-V Prescription Required Companion Animal

PestiGon Combo 402 mg / 361.8 mg Spot-on Solution for Very Large Dogs

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4421

What it's used for

For the treatment of dogs weighing over 40 kg bodyweight: To be used against infestations with fleas, alone or in association with ticks and/or biting lice...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

PestiGon Combo 402 mg / 361.8 mg Spot-on Solution for Very Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of dogs weighing over 40 kg bodyweight:
To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
•Ctenocephalides
against new infestations with adult fleas persists for 8 weeks. Prevention of
the multiplication of fleas by inhibiting the development of eggs (ovicidal
activity) and larvae and pupae (larvicidal activity) originating from eggs laid by
adult fleas for eight weeks after application.
•Ixodes ricinus
Dermacentor reticulatus
persistent acaricidal efficacy for up to 4 weeks against ticks.
•Trichodectes canis

Revised: April 2022
AN: 01198/2021 & 01199/2021Page 2 of 7
The product can be used as part of a treatment strategy for the control of Flea
Allergy Dermatitis (FAD).
Dosage: one pipette of 4.02 ml per dog weighing over 40 kg, corresponding to a

Revised: April 2022
AN: 01198/2021 & 01199/2021Page 4 of 7
minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-
methoprene.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Route of administration: External use only, spot-on use.
Only remove pipette from sachet immediately prior to
use.
Method of Administration:
Remove the pipette from the outer sachet using scissors or fold along diagonal line
to expose nick; tear back at nick.
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Twist or snap back the tip.
Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible. Place the tip of the pipette on the skin and
squeeze the pipette several times to empty its contents completely and directly
onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.

Revised: April 2022
AN: 01198/2021 & 01199/2021Page 5 of 7
In the absence of available data, the product should not be used on puppies less
than 8 weeks old
Do not use in rabbits, as adverse reactions with even mortality could occur. In
absence of studies, the use of the product is not recommended in non-target
species. Do not use on sick (e.g. systemic diseases, fever) or convalescent
animals.
This product is specifically developed for dogs. Do not use in cats and ferrets, as
this could lead to overdosing.
Do not use in cases of hypersensitivity to the active substances or to any of
the excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (skin discoloration, local hair loss, itching, redness) and general
itching or hair loss have been reported after use. Excessive salivation, reversible
nervous signs (increased sensitivity to stimulation, depression, other nervous
signs), vomiting or respiratory symptoms have also been observed after use.
The frequency of adverse reactions is defined using the following convention:
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
If licking occurs, a brief period of excessive salivation may be observed due mainly
to the nature of the carrier.
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavorable.
Fleas from pets often infest the animal's basket, bedding and regular resting
areas such as carpets and soft furnishings which should be treated, in case of
massive infestation and at the beginning of the control measures, with a suitable
insecticide and vacuumed regularly.

Special precautions for use in
animals Avoid contact with the
animal’s eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided. Do not smoke,
drink or eat during the application. In case of accidental eye contact, immediately
and thoroughly rinse the eyes with clean water.

Revised: April 2022
AN: 01198/2021 & 01199/2021Page 3 of 7
If eye irritation persists seek medical advice and show the package leaflet or the
label to the physician. If contact with the skin occurs, wash hands with soap and
water.
People with a known hypersensitivity to insecticides or alcohol should avoid
contact with the veterinary medicinal product.
Wash hands after use.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product. In case of
accidental ingestion of product, seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It
is therefore recommended that animals are not treated during the day, but should
be treated during the early evening, and that recently treated animals are not
allowed to sleep with owners, especially children.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in water courses for 2 days after application.
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
None known.
Store in the original package in order to protect from light and moisture.
This veterinary medicinal product does not require any special temperature
storage conditions.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

Medication costs adding up?

Pet insurance can cover prescription medications. Find the right policy for your pet.

Compare insurance

Find cheaper vets near you

Compare vet consultation prices in your area. Save on procedures and get a prescription to buy medications online.