Pereprin 5 mg/ml Pour-on Solution for Cattle, Sheep and Goats

For effective use, the veterinary medicinal product should not be applied to areas of
the backline covered with mud or manure.
In cattle, rainfall before, during or after the application of the veterinary medicinal
product, has been shown to have no impact on its efficacy. It also has been
demonstrated that haircoat length has no impact on the veterinary medicinal
product's efficacy. The effect of rainfall and haircoat length on efficacy has not been
evaluated in sheep and goats.
In order to limit cross-transfer of eprinomectin, treated animals may be separated
from untreated animals. Non-compliance with this recommendation may lead to
residue violations in untreated animals and development of resistance to
eprinomectin.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of infestation based on its epidemiological
features, for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
It is recommended to further investigate cases of suspected resistance, using an
appropriate diagnostic method (e.g. Faecal Egg Count Reduction Test). Where the
results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode
of action should be used. Confirmed resistance should be reported to the marketing
authorisation holder or to the competent authorities.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported in
cattle while resistance to eprinomectin has been reported in goats and sheep within
the EU. However, resistance to other macrocyclic lactones has been reported in
nematode populations in cattle, sheep and goats within the EU, which may be
associated with side-resistance to eprinomectin.
AN: 02056/2024 & 02076/2024
The use of the veterinary medicinal product should take into account local
information about susceptibility of the target parasites, where available.
While mite and louse numbers decline rapidly following treatment, due to the feeding
habits of some mites, in some cases several weeks may be required for complete
eradication.

Special precautions for safe use in the target species:
For external use only.
The veterinary medicinal product should be applied only on healthy skin.
To avoid secondary reactions due to the death of Hypoderma larvae in the
oesophagus or in the spine, it is recommended to administer the veterinary medicinal
product at the end of warble fly activity and before the larvae reach their resting
sites.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product may be irritating to skin and eyes and may cause
hypersensitivity reactions. People with known hypersensitivity to eprinomectin,
butylhydroxytoluene or propylene glycol dicaprylocaprate should avoid contact with
the veterinary medicinal product.
Eprinomectin can be transferred to breast milk. Therefore, breast-feeding women
should handle the veterinary medicinal product with great care.
Avoid contact with eyes and skin.
Personal protective equipment consisting of rubber gloves, boots and waterproof
coat should be worn when handling the veterinary medicinal product.
Should clothing become contaminated, remove as soon as possible and launder
before re-use.
In case of accidental spillage on skin, wash the affected area immediately with soap
and water.
In case of accidental eye contact, flush eyes immediately with plenty of clean water.
Should irritation persist, seek medical advice and show the package leaflet or the
label to the physician.
Do not ingest. In case of accidental ingestion, rinse out mouth thoroughly with water,
seek medical advice immediately and show the package leaflet or label to the
physician.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Wash hands after use.
Special precautions for the protection of the environment:
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils
and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding
repeated use of eprinomectin (and products of the same anthelmintic class).
In order to reduce the risk to aquatic ecosystems, treated animals should not have
direct access to water bodies for two to five weeks after treatment.
AN: 02056/2024 & 02076/2024