Bimeprine 5 mg/ml Pour-on Solution for Cattle

Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
- Underdosing, which may be due to underestimation of bodyweight,
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported in
cattle within the EU. However, resistance to other macrocyclic lactones has been
reported in parasite species in cattle within the EU. Therefore, use of this product
should be based on local (regional, farm) epidemiological information about
susceptibility of nematodes and recommendations on how to limit further selection for
resistance to anthelmintics.
If there is a risk for re- infection, the advice of a veterinarian should be sought
regarding the need for and frequency of repeat administration.
For the best results the product should be part of a planned programme to control
both internal and external parasites of cattle based on the epidemiology of these
parasites.

Special precautions for safe use in the target species:
For external use only.
For effective use, the product should not be applied to areas of the backline covered
with mud or manure.
The product should be applied only on healthy skin.
To avoid adverse reactions due to the death of warble larvae in the oesophagus or
backbone, it is recommended to administer the product after the end of warble fly
activity and before the larvae reach their resting sites in the body; consult a
veterinary surgeon to know the appropriate treatment period.
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Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
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hypersensitivity (allergic reactions).
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recently treated animals.
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the product.
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If accidental skin contact occurs, wash the affected area immediately with soap
and water. If accidental eye exposure occurs, flush the eyes immediately with
water.
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launder before re-use.
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Avoid accidental ingestion of the product, including by hand to mouth contact. If
ingestion does occur, wash the mouth out with water and seek medical advice.
•
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Special precautions for the protection of the environment:
Eprinomectin is very toxic to aquatic organisms, is persistent in soils and may
accumulate in sediments. Faeces containing eprinomectin excreted onto pasture by
treated animals may temporarily reduce the abundance of dung feeding organisms.
Following treatment of cattle with the product, levels of eprinomectin that are
potentially toxic to dung fly species may be excreted over a period of more than 4
weeks and may decrease dung fly abundance during that period. In case of repeated
treatments with eprinomectin (as with products of the same anthelmintic class) it is
advisable not to treat animals every time on the same pasture to allow dung fauna
populations to recover.
Eprinomectin is inherently toxic to aquatic organisms. The product should be used
only according to the label instructions. Based on the excretion profile of
eprinomectin when administered as the pour-on formulation, treated animals should
not have access to watercourses during the first 7 days after treatment.