Eprecis 20 mg/ml Solution for Injection for Cattle, Sheep and Goats

Cattle, sheep and goats
Care should be taken to avoid the following practices because they increase the
risk of development of resistance and could ultimately result in ineffective
therapy:
●
an extended period of time.
●
misadministration of the product, or lack of calibration of the dosing
device (if any).
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different
mode of action should be used.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different
mode of action should be used.
If there is a risk for re-infection, the advice of a veterinarian should be sought
regarding the need for and frequency of repeat administration.
Cattle
Resistance to other macrocyclic lactones has been reported in parasite species
in cattle within the EU. Therefore, use of this product should be based on local

Revised: October 2025
AN: 01772/2025
(regional, farm) epidemiological information about susceptibility of nematodes
and recommendations on how to limit further selection for resistance to
anthelmintics.
Sheep and goats
Resistance to eprinomectin in parasite species in goats and sheep has been
reported within the EU. Therefore, use of this product should be based on local
(regional, farm) epidemiological information about susceptibility of nematodes and
recommendations on how to limit further selection for resistance to anthelmintics.

i). Special precautions for use in animals
Usual aseptic procedures for administration of a parenteral injection should be
followed.
Not to be used in other species; avermectins can cause fatalities in dogs, especially
Collies, Old English Sheepdogs and related breeds and crosses, and also in
turtles/tortoises.
The death of warble fly larvae in the oesophagus or spinal cord canal may lead to
secondary reactions. In order to avoid secondary reactions due to the death of
Hypoderma larvae in the oesophagus or the spine, it is recommended to
administer the product at the end of the period of fly activity and before the larvae
reach their resting site.
ii). Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known hypersensitivity to eprinomectin or to any of the excipients
should avoid contact with the veterinary medicinal product
The veterinary medicinal product causes serious eye irritation. Avoid contact with
the eyes. Wash any splashes from eyes immediately with water.
This product may cause neurotoxicity. Care should be taken when handling the
product to avoid self-injection. In case of accidental injection, seek medical
advice immediately and show the package leaflet or the label to the physician.
Avoid contact with the skin. Wash any splashes from skin immediately with
water. Avoid oral exposure. Do not eat, drink or smoke while handling the
veterinary medicinal product.
Wash hands after use.
The excipient glycerol formal may cause harm to the unborn child. In addition, the
active substance eprinomectin can be transferred to breast milk. Pregnant/breast-
feeding women and women of childbearing age should therefore avoid exposure
to this product.
Special precautions for the protection of the environment
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in
soils and may accumulate in sediments.

Revised: October 2025
AN: 01772/2025
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too
frequent and repeated use of eprinomectin (and products of the same anthelmintic
class) in cattle, sheep and goats.
The risk to aquatic ecosystems will be further reduced by keeping treated cattle,
sheep and goats away from water bodies for two to five weeks after treatment.
iii). Other precautions
None