POM-V Prescription Required

Parofor 140 mg/ml Solution for Use in Drinking Water/ Milk for Cattle (Pre-ruminant) and Pigs

Active ingredient: Paromomycin

Form

Solution

Species

Cattle Pigs

Manufacturer

Huvepharma NV

VMD MA No.

30282/4033

What it's used for

Cattle (newborn calves): Cryptosporidiosis Treatment of infections caused by diagnosed Cryptosporidium parvum, by reduction of diarrhoea and reduction of f...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Paromomycin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Parofor 140 mg/ml Solution for Use in Drinking Water/ Milk for Cattle (Pre-ruminant) and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle (newborn calves):
Cryptosporidiosis
Treatment of infections caused by diagnosed Cryptosporidium parvum, by reduction
of diarrhoea and reduction of faecal oocyst shedding. Administration has to start
within 24 hours after the onset of diarrhoea.
Pigs:
Colibacillosis
Treatment of gastro-intestinal infections caused by Escherichia coli susceptible to
paromomycin.

AN: 01734/2021 & 01735/2021
25-50 mg paromomycin sulfate per kg BW/day (equivalent to 0.125 – 0.25 ml of
veterinary medicinal product/kg BW/day).
Duration of treatment: 3-5 days.
Pigs:
For administration in drinking water.
25-40 mg paromomycin sulfate per kg BW/day (equivalent to 0.125 – 0.2 ml of
veterinary medicinal product/kg BW/day).
Duration of treatment: 3-5 days.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The use of suitably calibrated measuring equipment is recommended.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
ml veterinary medicinal product mean body weight (kg) of
product/ kg body weight / day x animals to be treated = … ml veterinary
Mean daily water/milk/milk replacer medicinal product per litre
consumption (l/animal) drinking water/milk/milk replacer
The intake of medicated water/milk /milk replacer depends on several factors
including the clinical conditions of the animals and the local conditions such as
ambient temperature and humidity. In order to obtain the correct dosage, drinking
water/milk/milk replacer uptake has to be monitored and the concentration of
paromomycin may need to be adjusted accordingly.
Medicated drinking water/milk/milk replacer and any stock solutions should be freshly
prepared by carefully mixing the veterinary medicinal product in the requisite quantity
of fresh potable water /milk/milk replacer every 6 hours (in milk/milk replacer) or every
24 hours (in water).

Do not use in cases of hypersensitivity to the active substance, to other
aminoglycosides or to any of the excipients.
Do not use in cases with impaired function of the kidneys or liver.
Do not use in ruminating animals.
Do not use in turkeys due to the risk of selection for antimicrobial resistance in
intestinal bacteria.
AN: 01734/2021 & 01735/2021

Cattle (pre-ruminant), pigs:
Rare
(1 to 10 animals / 10,000
animals treated):
Loose stoolUndetermined frequency
(cannot be estimated from
available data)
Nephropathy
Internal ear disorder
1
Aminoglycoside antibiotics such as paromomycin can cause nephro- and
ototoxicity.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Cross-resistance has been shown between paromomycin and some antimicrobials in
the aminoglycosides class in Enterobacterales
product should be carefully considered when susceptibility testing has shown
resistance to aminoglycosides because its effectiveness may be reduced.
Paromomycin selects for resistance and cross-resistances at high frequency against
a variety of other aminoglycosides among intestinal bacteria.

Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on identification and
susceptibility testing of the target pathogen(s) isolated from the animal. If this is not
possible, therapy should be based on epidemiological information and knowledge of
susceptibility of the target pathogen at farm level or at local/regional level. Use of the
veterinary medicinal product should be in accordance with official, national and
regional antimicrobial policies.
The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of water/milk animals should be treated parenterally using
a suitable injectable veterinary medicinal product following the advice of the
veterinarian.
The use of the veterinary medicinal product should be combined with good
management practices e.g. good hygiene, proper ventilation, no overstocking.
Since the veterinary medicinal product is potentially ototoxic and nephrotoxic, it is
recommended to assess kidney function.
Special care should be taken when considering administration of the veterinary
medicinal product to newborn animals due to the known higher gastrointestinal
absorption of paromomycin in neonates. This higher absorption could lead to an
increased risk of oto- and nephrotoxicity. The use of the veterinary medicinal product
in neonates should be based on a benefit/risk assessment by the responsible
veterinarian.
Prolonged or repeated use of the veterinary medicinal product should be avoided by
improving management practices and through cleansing and disinfection.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to paromomycin and may
decrease the effectiveness of treatment with aminoglycosides due to the potential for
crossresistance.
Aminoglycosides are considered as critical in human medicine. Consequently, they
should not be used as a first line treatment in veterinary medicine.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product contains paromomycin, which can cause allergic
reactions in some people.
People with known hypersensitivity to paromomycin should avoid contact with the
veterinary medicinal product.
Avoid contact with the skin and eyes.
AN: 01734/2021 & 01735/2021
Personal protective equipment consisting of protective clothing and impervious
gloves should be worn when handling the veterinary medicinal product.
In case of accidental contact with the skin or eyes, rinse with plenty of water.
If you develop symptoms following exposure, such as skin rash, you should seek
medical advice and show the package leaflet or the label to the physician. Swelling of
the face, lips and eyes or difficulty in breathing are more serious symptoms and
require urgent medical attention.
Do not eat, drink and smoke when handling the veterinary medicinal product.
Do not ingest. In case of accidental ingestion or spillage onto skin, seek medical
advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

General anaesthetics and muscle relaxing products increase the neuro-blocking
effect of aminoglycosides. This may cause paralysis and apnoea.
Do not use concurrently with strong diuretics and potentially oto- or nephrotoxic
substances.

Do not store above 25°C.
After reconstitution, this veterinary medicinal product does not require any special
storage conditions.

Cattle (pre-ruminant)
Meat and offal: 20 days
Pigs
Meat and offal: 3 days
AN: 01734/2021 & 01735/2021
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.