POM-V Prescription Required

Gabbrovet Multi 140 mg/ml Solution for Use in Drinking Water/Milk for Pre-ruminant Cattle and Pigs

Active ingredient: Paromomycin

Form

Solution

Species

Cattle Pigs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/3082

What it's used for

Cattle (newborn calves): Cryptosporidiosis Treatment of infections caused by diagnosed Cryptosporidium parvum, by reduction of diarrhoea and reduction of f...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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2

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Prescription required

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Clinical information

Gabbrovet Multi 140 mg/ml Solution for Use in Drinking Water/Milk for Pre-ruminant Cattle and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle (newborn calves):
Cryptosporidiosis
Treatment of infections caused by diagnosed Cryptosporidium parvum, by reduction
of diarrhoea and reduction of faecal oocyst shedding. Administration has to start
within 24 hours after the onset of diarrhoea.
Pigs:
Colibacillosis
Treatment of gastro-intestinal infections caused by Escherichia coli susceptible to
paromomycin.

To ensure a correct dosage bodyweight should be determined as accurately as
possible.
Cattle (pre-ruminant cattle):
Colibacillosis
Duration of treatment: 3-5 days.
Administration in milk/milk replacer.
Recommended dosage: 1.25 – 2.5 ml of veterinary medicinal product/10 kg BW/day,
equivalent to 17500 - 35000 IU of paromomycin per kg BW/day (i.e. approximately
25-50 mg paromomycin sulfate per kg BW/day).
Cattle (newborn calves):
Cryptosporidiosis
Duration of treatment: 5 days.
Administration in milk/milk replacer or directly in the mouth using either a syringe or
an appropriate device for oral administration.
Recommended dosage: 7.5 ml of veterinary medicinal product/10 kg BW/day for 5
consecutive days, i.e. 105000 IU of paromomycin per kg BW/day for 5 consecutive
days (i.e. approximately 150 mg paromomycin sulfate per kg BW/day).
In case of insufficient uptake of milk, the totality of the remaining solution should be
administered orally directly into the mouth of the animal.
Pigs:
Colibacillosis
Duration of treatment: 3-5 days.
Administration in drinking water.
Recommended dosage: 1.25 – 2 ml of veterinary medicinal product/10 kg BW/day,
equivalent to 17500 - 28000 IU of paromomycin per kg BW/day (i.e. approximately
25-40 mg paromomycin sulfate per kg BW/day).
For the administration through the drinking water the exact daily amount of veterinary
medicinal product should be based on the number of the animals to be treated, and
the recommended dose calculated according to the following formula:
ml product/ kg BW/day x Mean bodyweight (kg)
of animals to be treated ml product per litre
= drinking water/day/animal
Mean daily water consumption (litre) per animal
The uptake of medicated water depends on several factors including clinical
conditions of the animals and the local conditions such as ambient temperature and
humidity. In order to obtain the correct dosage, uptake of drinking water has to be
monitored and the concentration of paromomycin has to be adjusted accordingly.
Medicated drinking water/milk/milk replacer and any stock solutions should be freshly
prepared every 6 hours (in milk/milk replacer) or every 24 hours (in water).

Do not use in cases of hypersensitivity to paromomycin, to other aminoglycosides or
to any of the excipients.
Do not use in cases with impaired function of the kidneys or liver.
Do not use in ruminating animals.
Do not use in turkeys due to the risk of selection for antimicrobial resistance in
intestinal bacteria.

Cattle (pre-ruminant cattle and newborn calves) and pigs:
Rare
(1 to 10 animals / 10,000
animals treated):
Soft faeces
Unknown frequencies
Aminoglycoside antibiotics such as paromomycin
can cause oto- and nephrotoxicity.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the last section of the package leaflet for
respective contact details.

Cross-resistance has been shown between paromomycin and neomycin in
Enterobacterales. Use of the product should be carefully considered when
susceptibility testing has shown resistance to aminoglycosides because its
effectiveness may be reduced.

Special precautions for safe use in the target species:
The use of the veterinary medicinal product should be combined with good
management practices e.g. good hygiene, proper ventilation, no overstocking.
Since the product is potentially ototoxic and nephrotoxic, it is recommended to
assess kidney function. Special care should be taken when considering
administration of the veterinary medicinal product to newborn animals due to the
known higher gastrointestinal absorption of paromomycin in neonates. This higher
absorption could lead to an increased risk of oto-and nephrotoxicity. The use of the
veterinary medicinal product in calves of 5 days or less should be based on benefit-
risk assessment by the responsible veterinarian.
As with any antiparasiticide, frequent and repeated use of antiprotozoals from the
same class may lead to the development of resistance.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
Colibacillosis
The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of water/milk animals should be treated parenterally using
a suitable injectable veterinary medicinal product following the advice of the
veterinarian.
Prolonged or repeated use of the veterinary medicinal product should be avoided by
improving management practices and through cleansing and disinfection.
Use of the product should be based on identification and susceptibility testing of the
target pathogen(s). If this is not possible, therapy should be based on
epidemiological information and knowledge of susceptibility of the target pathogens
at farm level, or at local/regional level.
Use of the veterinary medicinal product deviating from the given instructions may
increase the prevalence of bacteria resistant to paromomycin and may decrease the
effectiveness of treatment with aminoglycosides due to the potential for cross-
resistance.
Aminoglycosides are considered as critical in human medicine. Consequently, they
should not be used as a first intention antimicrobial treatment in veterinary medicine.
Cryptosporidiosis
Calves should only receive the treatment upon confirmation of cryptosporidial
oocysts in their faeces.
The product should only be used in individual animals.
Not for use for prophylaxis or metaphylaxis.
If applicable, antibiotic-free options should be preferred, in line with responsible use
of antibiotics.
Do not use on an empty stomach. For treatment of anorexic calves, the product
should be administered in half a litre of an electrolyte solution. The animals should
receive enough colostrum according to good breeding practice.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product contains paromomycin and benzyl alcohol, which
can cause allergic reactions in some people.
People with known hypersensitivity (allergy) to paromomycin or any other
aminoglycosides and/or benzyl alcohol should avoid contact with the veterinary
medicinal product.
This product is slightly irritant to the eye. Avoid contact with the skin and eyes.
Personal protective equipment consisting of protective clothing and impervious
gloves should be worn when handling the veterinary medicinal product.
In the event of accidental contact with the skin or eyes, rinse with plenty of water.
If you develop symptoms following exposure, such as skin rash, you should seek
medical advice and show the physician this warning. Swelling of the face, lips and
eyes or difficulty in breathing are more serious symptoms and require urgent medical
attention.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the label to the physician.
Wash hands after use.
Do not eat, drink and smoke when handling the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.

General anaesthetics and muscle relaxing products increase the neuro-blocking
effect of aminoglycosides. This may cause paralysis and apnoea.
Do not use concurrently with strong diuretics and potentially oto- or nephrotoxic
substances.

125 ml and 250 ml HDPE bottles:
Do not store above 25°C.
500 ml and 1-litre HDPE bottles:
This veterinary medicinal product does not require any special storage conditions.
250 ml, 500 ml and 1-litre HDPE/EVOH/HDPE bottles:
This veterinary medicinal product does not require any special storage conditions.
All presentations:
After first opening, keep the bottle tightly closed.

Cattle (pre-ruminant cattle and newborn calves):
- Colibacillosis:Dosage: 25-50 mg/kg/day for 3 to 5 days. Meat and offal: 20 days
- Cryptosporidiosis: Dosage: 150 mg/kg/day for 5 days. Meat and offal: 110 days
Pigs: Meat and offal: 3 days
Due to the accumulation of paromomycin in the liver and kidneys, any repeated
courses of treatment during the withdrawal period should be avoided.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.