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POM-V Prescription Required

Orbeseal Dry Cow 2.6g Intramammary Suspension

Active ingredient: Bismuth Subnitrate

Form

Intramammary

Species

Cattle

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3063

What it's used for

In cows considered likely to be free of sub-clinical mastitis, the veterinary medicinal product can be used on its own in dry cow management and mastitis c...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Bismuth Subnitrate

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Orbeseal Dry Cow 2.6g Intramammary Suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

In cows considered likely to be free of sub-clinical mastitis, the veterinary
medicinal product can be used on its own in dry cow management and
mastitis control.
Infuse the contents of one intramammary syringe of the veterinary medicinal
product into each udder quarter immediately after the last milking of the
lactation (at drying off.). Do not massage the teat or udder after infusion of the
veterinary medicinal product.
Care must be taken not to introduce pathogens into the teat in order to reduce
the risk of post-infusion mastitis.
It is essential that the teat is thoroughly cleaned and disinfected, with surgical
spirit or alcohol-impregnated wipes. The teats should be wiped until the wipes
are no longer visibly dirty. Teats should be allowed to dry prior to infusion.
Infuse aseptically and take care to avoid contamination of the syringe nozzle.
Following infusion it is advisable to use an appropriate teat dip or spray.
Under cold conditions the veterinary medicinal product may be warmed to room
temperature in a warm environment, to aid syringeability.
See section 3.7 “Use during pregnancy, lactation or lay”. Do not use the
veterinary medicinal product alone in cows with sub-clinical mastitis at drying
off. Do not use in cows with clinical mastitis at drying off.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Cattle (dairy cow at drying-off).
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Acute mastitis
.
Primarily due to poor infusion technique and lack of hygiene.

Please refer to
sections 3.5 “Special precautions for use” and 3.9 “Administration routes and
dosage” regarding the importance of aseptic technique.
Reporting adverse events is important. It allows continuous safety monitoring
of a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See also ‘Contact details’ section of the package leaflet.
Selection of cows for treatment with the veterinary medicinal product should
be based on veterinary clinical judgement. Selection criteria may be based on
the mastitis and cell count history of individual cows or recognised tests for
the detection of subclinical mastitis or bacteriology sampling.

Special precautions for safe use in the target species:
It is good practice to observe dry cows regularly for signs of clinical mastitis.
If a sealed quarter develops clinical mastitis, the affected quarter should be
stripped out manually before appropriate therapy is instituted.
To reduce the risk of contamination, do not immerse the syringe in water.
Use the syringe only once.
Since the veterinary medicinal product does not have antimicrobial activity, in
order to minimize the risk of acute mastitis due to poor infusion technique and
lack of hygiene (see section
interaction
In clinical trials, the compatibility of the veterinary medicinal product has only
been shown with a cloxacillin-containing dry cow preparation.
See also section 3.5 “Special precautions for safe use in the target species”.
This veterinary medicinal product does not require any special storage
conditions.
Meat and offal: Zero days.
Milk: Zero hours.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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