DrySeal 2.6 g Intramammary Suspension for Cattle
Active ingredient: Bismuth Subnitrate
Form
Intramammary
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/3000
What it's used for
In cows considered likely to be free of sub-clinical mastitis, the veterinary medicinal product can be used on its own in dry cow management and mastitis c...
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Prescription required
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DrySeal 2.6 g Intramammary Suspension for Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
product can be used on its own in dry cow management and mastitis control.
into each udder quarter immediately after the last milking of the lactation (at drying
off). Do not massage the teat or udder after infusion of the veterinary medicinal
product because it is important that the sealant stays in the teat itself and does not
enter the udder.
Care must be taken not to introduce pathogens into the teat to reduce the risk of post
infusion
mastitis.
It is essential that the teat is thoroughly cleaned and disinfected before infusion, with
the alcohol-impregnated wipes provided or equivalent. The teats should be wiped
until the wipes are no longer visibly dirty. Teats should be allowed to dry prior to
infusion. Infuse aseptically and take care to avoid contamination of the syringe
nozzle. Following infusion, it is advisable to use an appropriate teat dip or spray.
The veterinary medicinal product has a dual tip nozzle (see Figure 1). The cap of the
syringe can be partially or fully removed. It is recommended to pinch the teat at the
teat base as it aids in positioning the paste in the teat cistern, sealing the teat canal
from the top.
Figure 1
Option 1: The short nozzle option allows for a partial insertion to minimize intrusion
into the teat.
Option 2: The long nozzle option may be used for treatment convenience for example
to help keep the tip inserted during administration to a moving or nervous cow.
Option 1: For short nozzle intramammary administration hold the barrel of the
intramammary syringe and the base of the cap in one hand and twist off the small
upper part of the cap above the indent mark (the base portion of the cap remains on
the intramammary syringe) Take care not to contaminate the nozzle.
Option 2: For full nozzle intramammary administration remove the cap fully by holding
the barrel of the intramammary syringe firmly on one hand and with the thumb push
up and along the length of the cap until the cap clicks off. Take care not to
contaminate the nozzle.
Under cold conditions the veterinary medicinal product may be warmed to room
temperature in a warm environment, to aid syringeability.
Do not use in lactating cows.
Do not use the veterinary medicinal product alone in cows with sub-clinical mastitis.
Do not use in cows with clinical mastitis.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Acute mastitis
1
Primarily due to poor infusion technique and lack of hygiene. Please refer to
sections 3.5 and 3.9 regarding the importance of aseptic technique.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder, or its local representative, or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
based on veterinary clinical judgement. Selection criteria may be based on the
mastitis and cell count history of individual cows or recognised tests for the detection
of subclinical mastitis or bacteriology sampling.
Special precautions for safe use in the target species:
It is good practice to observe dry cows regularly for signs of clinical mastitis. If a
sealed quarter develops clinical mastitis, the affected quarter should be stripped out
manually before appropriate therapy is instituted.
To reduce the risk of contamination, do not immerse the syringe in water.
Use the syringe only once.
Since the veterinary medicinal product does not have antimicrobial activity, it is
crucial to minimize the risk of acute mastitis due to poor infusion technique and lack
of hygiene (see section 3.6), follow the aseptic technique of administration described
in section 3.9.
In cows that may have sub-clinical mastitis, the veterinary medicinal product may be
used following administration of a suitable dry cow antibiotic treatment to the infected
quarter.
Do not administer any other intramammary product following administration of the
veterinary medicinal product.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product may cause skin and eye irritation. Avoid contact
with skin or eyes.
Should skin or eye contact occur, wash the affected area thoroughly with water.
If irritation persists, seek medical advice, and show the package leaflet or label to
the physician.
Bismuth salts have been associated with hypersensitivity reactions. If you know that
you are allergic to bismuth salts, avoid using this veterinary medicinal product. If you
develop symptoms following exposure, seek medical advice and show the package
leaflet or the label to the physician.
Wash hands after use.
Disinfectant wipes:
The disinfectant wipes may cause skin and eye irritation due to the presence of
isopropyl alcohol. Avoid eye contact. Avoid prolonged contact with skin. Avoid
inhalation of the vapour. The wearing of gloves may prevent skin irritation.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
bismuth subnitrate has only been shown with a cloxacillin-containing dry cow
preparation.
See also section 3.5.
Milk: Zero hours.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Bismuth Subnitrate
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Cepralock 2.6 g Intramammary Suspension for Dry Cows
POM-VIntervet International B.V.
Cepralock 2.6 g Intramammary Suspension for Dry Cows
POM-VIntervet International B.V.
DrySeal 2.6 g Intramammary Suspension for Cattle
POM-VElanco Europe Ltd
Fatroseal 2.6 g Intramammary Suspension for Dry Cows
POM-VFatro S.p.A.
Fatroseal 2.6 g Intramammary Suspension for Dry Cows
POM-VFatro S.p.A.
Mastic Seal 2.6 g Intramammary Suspension for Cattle
POM-VBioveta, a.s.
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