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POM-V Prescription Required

Orbeseal Dry Cow 2.6g Intramammary Suspension

Active ingredient: Bismuth Subnitrate

Form

Intramammary

Species

Cattle

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5106

What it's used for

Prevention of new intramammary infections throughout the dry period. In cows considered likely to be free of sub-clinical mastitis, the veterinary medicina...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Bismuth Subnitrate

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Orbeseal Dry Cow 2.6g Intramammary Suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Prevention of new intramammary infections throughout the dry period.
In cows considered likely to be free of sub-clinical mastitis, the veterinary
medicinal product can be used on its own in dry cow management and
mastitis control.
See section 4.7. Do not use the veterinary medicinal product alone in cows
with sub-clinical mastitis at drying off. Do not use in cows with clinical mastitis
at drying off.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.

Revised: December 2024
AN: 00709/2024
Cattle (dairy cow at drying-off).
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Acute mastitis
.

Revised: December 2024
AN: 00709/2024
Primarily due to poor infusion technique and lack of hygiene. Please refer to
sections 4.5 and 4.9 regarding the importance of aseptic technique.
Reporting adverse events is important. It allows continuous safety monitoring
of a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See also ‘Contact details’ section of the package leaflet.
Selection of cows for treatment with the veterinary medicinal product should
be based on veterinary clinical judgement. Selection criteria may be based on
the mastitis and cell count history of individual cows or recognised tests for
the detection of subclinical mastitis or bacteriology sampling.

Special precautions for safe use in the target species:
It is good practice to observe dry cows regularly for signs of clinical mastitis. If
a sealed quarter develops clinical mastitis, the affected quarter should be
stripped out manually before appropriate therapy is instituted.
To reduce the risk of contamination, do not immerse the syringe in water.
Use the syringe only once.
Since the veterinary medicinal product does not have antimicrobial activity, in
order to minimize the risk of acute mastitis due to poor infusion technique and
lack of hygiene (see section 4.6), it is crucial to follow the aseptic technique of
administration described in section 4.9.
Do not administer any other intramammary product following administration of
-the product. In cows that may have sub-clinical mastitis, the veterinary
medicinal product may be used following administration of a suitable dry cow
antibiotic treatment to the infected quarter.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
This veterinary medicinal product may cause skin and eye irritation.
Avoid contact with skin or eyes.
Should skin or eye contact occur, wash the affected area thoroughly with
water.
If irritation persists, seek medical advice and show this label to the physician.
People with known hypersensitivity to bismuth salts should avoid contact with
the veterinary medicinal product.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
interaction
In clinical trials, the compatibility of the veterinal medicinal product has only
been shown with a cloxacillin-containing dry cow preparation.
See also section 4.5 “Special precautions for safe use the target species”.
This veterinary medicinal product does not require any special storage
conditions.

Revised: December 2024
AN: 00709/2024
Meat and offal: Zero days.
Milk: Zero hours.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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