NexGard Combo spot-on solution for cats 2.5-7.5 kg

If there is a risk for re-infestation, the advice of a veterinarian should be sought
regarding the need for and frequency of repeat administration.
Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:
•
over an extended period of time.
•
misadministration of the product, or lack of calibration of the dosing
device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported
within the EU. However resistance to other macrocyclic lactones has been reported
in parasite species in cattle within the EU. Therefore, use of this product should be
based on local (regional, farm) epidemiological information about susceptibility of
nematodes and recommendations on how to limit further selection for resistance to
anthelmintics.
While mite and louse numbers decline rapidly following treatment, due to the feeding
habits of the parasites, in some cases several weeks may be required for complete
eradication.
AN: 01447/2024 & 01448/2024
For effective use, the product should not be applied to areas of the backline covered
with mud or manure.
For the best results the product should be part of a program to control both internal
and external parasites of cattle based on the epidemiology of these parasites.

Special precautions for safe use in the target species:
To avoid secondary reactions due to the death of Hypoderma larvae in the
oesophagus or in the spine, it is recommended to administer the product at the end
of warble fly activity and before the larvae reach their resting sites.
Rainfall at any time before or after treatment will not affect the efficacy of the
product.
The product should be applied only to healthy skin.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This product may be irritating to human skin and eyes and may cause
hypersensitivity.
Avoid skin and eye contact with the product during treatment and when handling
recently treated animals.
Personal protective clothing consisting of rubber gloves, boots and a waterproof coat
should be worn when applying the product.
Should clothing become contaminated, remove as soon as possible and launder
before re-use.
In case of accidental spillage onto skin, seek medical advice immediately and show
the package leaflet or the label to the physician.
If accidental eye exposure occurs, flush eyes immediately with water.
This product may be toxic after accidental ingestion.
Avoid accidental ingestion of the product by hand to mouth contact.
Do not smoke, eat or drink while handling the product.
In the event of ingestion, wash out mouth with water and seek medical advice.
Wash hands after use.
This product is flammable. Keep away from sources of ignition.
Inhalation of the product may cause irritation.
Use only in well ventilated areas or outdoors.
AN: 01447/2024 & 01448/2024
Special precautions for the protection of the environment:
Eprinomectin is very toxic to dung fauna and aquatic organisms and may accumulate
in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too
frequent and repeated use of eprinomectin (and products of the same anthelmintic
class) in cattle.
The risk to aquatic ecosystems will be further reduced by keeping treated cattle
away from water bodies for two to four weeks after treatment.
Other precautions:
Not to be used in other species; avermectins can cause fatalities in dogs, especially
Collies, Old English Sheepdogs and related breeds and crosses, and also in
turtles/tortoises.