Luteoplan 250 micrograms/ml Solution for Injection for Cattle and Horses

Cattle (cows and heifers):
Rare
(1 to 10 animals / 10,000
animals treated):
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Abdominal pain
, Diarrhoea
3,5
;
Incoordination
;
Lying down
;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
;
Restlessness, Frequent urination
3,5
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic
therapy, particularly covering clostridial species, should be employed at the first
sign of infection. Careful aseptic techniques should be employed to decrease
the possibility of these infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin F2α

in the
smooth muscles.
May be caused by induction of parturition or abortion. As part of induction of
parturition, depending on the date of treatment versus the date of conception,
the incidence of placental retention may be increased.
In case of occurrence, these effects are observed within 15 minutes post-
injection and usually disappear after one hour.

Revised: March 2026
AN: 01224/2025
Horses (mares):
Uncommon
(1 to 10 animals / 1,000 animals
treated):
Abnormal oestrus
Rare
(1 to 10 animals/ 10,000
animals treated):
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Increased sweating
4,5
;
Abdominal pain
, Colic
, Diarrhoea
4,8
;
Incoordination
, Muscle tremor
;
Lying down
, Decreased body temperature
;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
;
Restlessness, Frequent urination
4,8
Haemorrhagic (anovular) follicles and multiple ovulations are reported in
literature for horses treated with cloprostenol.
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic
therapy, particularly covering clostridial species, should be employed at the first
sign of infection. Careful aseptic techniques should be employed to decrease
the possibility of these infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin F2α activity in the
smooth muscles.
Appears to be transient and resolves without any treatment.
Mild.
May be caused by termination of gestation, depending on the date of
treatment versus the date of conception, the incidence of placental retention
may be increased.
In case of occurrence, these effects are observed within 15 minutes post-
injection and usually disappear after one hour.
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See the package leaflet for respective contact details.