POM-V Prescription Required

Cyclix 250 microgram/ml Solution for Injection for Cattle

Active ingredient: Cloprostenol

Form

Injection

Species

Cattle

Manufacturer

Virbac

VMD MA No.

05653/5038

What it's used for

Induction of luteolysis allowing resumption of oestrus and ovulation in cyclic females when used during dioestrus, synchronisation of oestrus (within 2 to...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Cloprostenol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Cyclix 250 microgram/ml Solution for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Induction of luteolysis allowing resumption of oestrus and ovulation in cyclic females
when used during dioestrus, synchronisation of oestrus (within 2 to 5 days) in groups
of cyclic females treated simultaneously, treatment of suboestrus and uterine
disorders related to a functioning or persistent corpus luteum (endometritis,
pyometra), treatment of ovarian luteal cysts, induction of abortion until day 150 of
pregnancy, expulsion of mummified foetuses, induction of parturition.

For all indications, 2 ml corresponding to 0,5 mg cloprostenol/animal, injected
intramuscularly.
In order to synchronise oestrus in groups of females, it is recommended that the
product is administered on two occasions with a between treatment interval of 11
days.

Do not use in pregnant animals, for which induction of abortion or parturition is not
intended. Do not use in animals with spastic diseases of the respiratory or
gastrointestinal tract.

Revised: July 2023
Divergence from NI MA following AN: 00681/2022Page 2 of 5

Anaerobic infection may occur if anaerobic bacteria penetrate the tissue at injection
site, in particular following intramuscular injection.
When used for induction of parturition and dependent on the time of treatment
relative to the date of conception, the incidence of retained placenta may be
increased.
In very rare cases, anaphylactic-type reactions can be observed which might be life-
threatening and require rapid medical care.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated, displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated )
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

None

Special precautions for use in animals
As with parenteral administration of any substance, basic aseptic rules should be
observed. The injection site must be thoroughly cleaned and disinfected in order to
reduce the risk of infection with anaerobic bacteria.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known hypersensitivity to benzyl alcohol should avoid contact with the
product.
Do not eat, drink or smoke while handling the product.
Direct contact with skin or mucous membranes of the user should be avoided.
Prostaglandins of the F2α type may be absorbed through the skin and may cause
bronchospasm or miscarriage. The product must be handled carefully to avoid
ACCIDENTAL SELF-INJECTION OR SKIN CONTACT. Pregnant women, women in
childbearing age, asthmatics and persons with other respiratory tract diseases should
exercise caution when handling cloprostenol. Those persons should wear rubber (or
plastic) gloves during administration of the product. Accidental spillage on the skin
should be washed immediately with soap and water.
In case of accidental self-injection, seek medical advice immediately and show the
package insert or the label to the physician.

Concurrent use of oxytocin and cloprostenol increases effects on the uterus. The
activity of other oxytocic agents can be increased after the administration of
cloprostenol.
Do not use in animals being treated with non-steroidal anti-inflammatories, as the
synthesis of endogenous prostaglandins is inhibited.

Keep the vial in the outer carton
Protect from light.

Cattle:
Meat and offal: 2 days
Milk: Zero days
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.