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POM-V Prescription Required

Bioestrovet Swine 0.0875 mg/ml Solution for Injection for Pigs

Active ingredient: Cloprostenol

Form

Injection

Species

Pigs

Manufacturer

Vetoquinol UK Limited

VMD MA No.

08007/5000

What it's used for

In sows and gilts: - Induction of farrowing from day 114 of pregnancy onwards (day 1 of pregnancy is the last day of insemination).

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Cloprostenol

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Bioestrovet Swine 0.0875 mg/ml Solution for Injection for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

In sows and gilts:
- Induction of farrowing from day 114 of pregnancy onwards (day 1 of pregnancy is the
last day of insemination).
Intramuscular use.
A single dose of 0.175 mg cloprostenol (as cloprostenol sodium) per animal
corresponding to 2 mL of product per animal once, by deep intramuscular injection,
preferably with a needle of at least 5 cm long.
It is recommended that the vial is not broached more than 10 times with a 21G needle
(or finer) and that the appropriate vial size is used for prevailing usage conditions.
Otherwise, an automatic syringe equipment, or a suitable draw-off needle, should be
used for the 50 ml vials to avoid excessive puncturing of the stopper.
Having calculated the average gestation length for each farm, sows and gilts may be
injected two days before this date or on any date thereafter to suit the requirements of
the particular management system. Trials carried out two days before the average
term have shown that normally 95% of animals will commence farrowing within 36
hours of treatment. The majority of animals can be expected to respond within the
period 24±5 hours following injection, and earlier if farrowing had already almost
spontaneously begun.
Do not use in pregnant animals unless the objective is to terminate the pregnancy.
Do not use in animals with cardiovascular, gastro-intestinal or respiratory
disturbances.
Do not use to induce parturition in sows with suspected dystocia due to mechanical
obstruction or if problems are expected because of an abnormal position of the foetus.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use intravenously.
Revised: October 2023
AN: 01832/2023
An anaerobic infection can occur when anaerobic bacteria enter the injection site,
particularly following intramuscular injection.
When used in sows and gilts for induction of parturition and dependent on the time of
treatment relative to the date of conception, the incidence of retained placenta may be
increased.
In very rare cases transient erythema and pruritus, urination and defecation, ataxia,
hyperpnea, dyspnea, nest-building behaviors, abdominal muscle spasms,
vocalization and salivation may occur following the administration of prostaglandin
F2
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
Revised: October 2023
AN: 01832/2023
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Special precautions for use in animals
Induction of farrowing too early in pregnancy can lead to non-viable piglets being
born. An increase in the number of non-viable piglets may result if used more than
two days prior to the average gestation length calculated from farm records.
To reduce the risk of anaerobic infections, potentially related to the pharmacological
properties of prostaglandins, avoid injecting through an area of contaminated skin.
Clean and disinfect carefully the injection sites before administration.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Prostaglandins of the
skin and mucous membranes and may cause bronchospasm or miscarriage.
Care should be taken when handling the product to avoid self-injection or skin
contact.
Pregnant women, women of child-bearing age, asthmatics and people with bronchial
or other respiratory problems must avoid any contact with the product.
This product may cause hypersensitivity (allergic) reactions. People with known
hypersensitivity to benzyl alcohol should avoid contact with the product.
Wear disposable impervious gloves when administering the product.
Wash hands after use.
Accidental spillage on the skin should be washed off immediately with soap and
water.
In case of accidental self-injection or spillage onto the skin, seek medical advice and
show the package leaflet or label to the physician.
Should shortness of breath occur, seek medical advice immediately and show the
package leaflet or label to the physician. Do not eat, drink or smoke while handling
the product.
Concomitant use of oxytocin and cloprostenol increases the effects on the uterus.
Do not administer the product together with non-steroidal anti-inflammatory drugs
since they inhibit endogenous prostaglandin synthesis.
Keep the vial in the outer carton in order to protect from light.

Revised: October 2023
AN: 01832/2023
Meat and offal: 2 days
Revised: October 2023
AN: 01832/2023
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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