POM-V Prescription Required

Lismay 222 mg/g + 444.7 mg/g Powder for Use in Drinking Water

Active ingredients: Lincomycin, Spectinomycin

Form

Powder

Species

Pigs

Manufacturer

Laboratorios Maymo S.A.

VMD MA No.

42204/4003

What it's used for

For the treatment and metaphylaxis of porcine proliferative enteropathy (ileitis) caused by and associated enteric pathogens (Escherichia coli) susceptible...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Lincomycin + Spectinomycin

1

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2

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Prescription required

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Clinical information

Lismay 222 mg/g + 444.7 mg/g Powder for Use in Drinking Water — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment and metaphylaxis of porcine proliferative enteropathy (ileitis)
caused by and associated enteric pathogens
(Escherichia coli) susceptible to lincomycin and spectinomycin.
The presence of the disease in the group must be established before the product
is used.

For use in drinking water.
The recommended dosage rates are: 3.33 mg lincomycin and 6.67 mg
spectinomycin/kg bw/day, for 7 days. This amounts to 15 mg powder/kg bw/day
for 7 days.
Treatment should be initiated as soon as first clinical signs occur.

Amended pages: October 2025
For the preparation of drinking water, the incorporation rate of the veterinary
medicinal product in water will depend on the body weight of the animals and
their actual daily intake of water.
To ensure a correct dosage and avoid underdosing, mean body weights in the
group of animals and daily water consumption should be determined as
accurately as possible.
The medicated drinking water should be the sole source of drinking water for the
treatment duration. Any medicated water which is not consumed within 24 hours
should be discarded.
Sufficient medicated drinking water should be prepared to cover only the daily
requirements.
In case of disease accompanied with significant decrease in water intake,
parenteral treatment may have to be initiated.
Use the following indications as a basis for the precise calculation of incorporation
rate of the veterinary medicinal product in drinking water.
To determine the volume of dilution (in litres of drinking water) required for 150 g
of the veterinary medicinal product, use the following formula:
10,000 x [daily water consumption per
animal (L)]
Volume (L) for 150 g of
the veterinary medicinal
product
=
Average body weight of one pig (kg)
150 g of the veterinary medicinal product corresponds to the dose for 10,000 kg
of body weight per day.
As an indication, standard water intake varies around 0.15 L/kg bw/day. The table
below shows the volume of water to be used for dilution of 150 g of the veterinary
medicinal product.
Water
consumption
150 g of powder = 100 g antibiotic activity should be diluted
in…
0.1 L/kg bw/day1,000 L of drinking water0.15 L/kg bw/day1,500 L of drinking water0.2 L/kg bw/day2,000 L of drinking water0.25 L/kg bw/day2,500 L of drinking water
The maximum solubility of the product in water is 150 g per litre. For stock
solutions and when using a proportioner/dosing pump, take care not to exceed
the maximum solubility. Adjust flow rate settings of the proportioner/dosing pump
according to concentration of the stock solution and water intake of the animals
to be treated.

Amended pages: October 2025

Do not use in known cases of hypersensitivity to the active substances or any of
the excipients.
Do not use in known cases of hepatic dysfunction.
Do not allow rabbits or rodents (eg chinchillas, hamsters, guinea pigs), horses
or ruminants to access to water or feed containing lincomycin. Ingestion by
these species may result in severe gastrointestinal effects.

Amended pages: October 2025

Cases of diarrhoea or soft faeces and/or perianal region inflammation have been
encountered in healthy pigs at the start of treatment. The symptoms disappeared
within 5 to 8 days without interruption of the treatment.
Rare cases of irritability/excitation, skin rash/pruritus were also observed.
Allergic/hypersensitive reactions are rare but can occur and require stopping
treatment with the veterinary medicinal product. A symptomatic treatment must
be implemented.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).

In , a significant part of the strains show high MIC values (minimum
inhibitory concentrations) against the lincomycin and spectinomycin combination
and may be clinically resistant, although no breakpoint is defined.
Due to technical constraints, the susceptibility of is difficult to test
in vitro, and data about lincomycin -spectinomaycin resistance status in that
species are lacking.

Special precautions for use in animals
It is sound clinical practice to base treatment on susceptibility testing of the
bacteria isolated from the animal. If this is not possible, therapy should be based
on local (regional, farm level) epidemiological information about susceptibility of
target bacteria. Use of the veterinary medicinal product deviating from the
instructions in the SPC may increase the risk of development and selection of
resistant bacteria and decrease the effectiveness of treatment with macrolides
due to the potential for cross-resistance.
The oral use of preparations containing lincomycin is only indicated in swine. Do
not leave access to the medicated water for other animals. Lincomycin may lead
to severe gastrointestinal disturbances in other animal species.
The repeated or prolonged use should be avoided, by improving the farm
management and disinfection practices.
Diagnosis should be reconsidered if improvement is not seen after 5 days.
Sick animals have a reduced appetite and an altered drinking pattern, and
severely affected animals may therefore require parenteral treatment.
This powder is for use in drinking water only and should be dissolved before use.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known hypersensitivity to lincomycin, spectinomycin or soybean
millfeed should avoid contact with the veterinary medicinal product.
This product may cause skin, respiratory and eye irritation.
Care should be taken not to raise and inhale any dust.
Contact with skin and eyes should be avoided.
Personal protective equipment consisting of approved dust masks (either a
disposable half mask respirator conforming to European Standard EN149 or a
non-disposable respirator conforming to European Standard EN 140 with a filter
EN 143), gloves and safety glasses should be worn when handling and mixing
the product.
Wash hands and any exposed skin with soap and water immediately after use.

Amended pages: October 2025
If symptoms such as skin rash, persistent cough or persistent eye irritation appear
after exposure, seek medical advice immediately and show the package leaflet
or label to the physician.

In general mixture with other medicines should be avoided.
The combination of lincosamides and macrolides is antagonistic, due to
competitive binding to their target sites. Combination with anaesthetics may lead
to possible neuromuscular blocking.
Do not administer with kaolin or pectine as they impair lincomycin absorption. If
co-administration is mandatory, respect a delay of two hours between intakes.

This veterinary medicinal product does not require any special storage conditions
Keep the container tightly closed. After use, fold over the top of the bag and
secure with a clip.

Meat and offal: Zero days.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.