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AVM-GSL Over the Counter Companion Animal

Katkin DE:FLEA 50 mg/60 mg Spot-on Solution for Cats

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Cats

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/5028

What it's used for

To be used against infestations with fleas, alone or in association with ticks and/or biting lice: -Ctenocephalides spp.). Insecticidal efficacy against ne...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for (S)-Methoprene + Fipronil

  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

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    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Katkin DE:FLEA 50 mg/60 mg Spot-on Solution for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

To be used against infestations with fleas, alone or in association with ticks and/or
biting lice:
-Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for six weeks after
application.
-Ixodes ricinus, Dermacentor variabilis, Rhipicephalus
sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks
against ticks (based on experimental data).
-Felicola subrostratus).

Revised: January 2025
AN: 03104/2023
For external use only, topical spot-on application to the skin. Animals should be
weighed accurately prior to treatment.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5
mg/kg for fipronil and 6 mg/kg for S-methoprene, by topical application to the skin. Do
not overdose. In the absence of safety studies, the minimum treatment interval is 4
weeks.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible.
4. Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
In the absence of available data, the product should not be used on kittens less than
8 weeks old and/or weighing less than 1 kg.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use if your cat has a hypersensitivity (allergy) to the active substances (fipronil
or (S)-methoprene) or to any other excipients (ingredients).
Do not use in rabbits, as adverse drug reactions, including death, could occur.
Do not use in any other non-target species.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use. Excessive salivation, reversible nervous signs
(increased sensitivity to stimulation, depression, other nervous signs) or vomiting
have also been observed after use.
Cat:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site skin scaling, hair loss, itching,
redness*
Generalised itching or hair loss
Undetermined frequency
(cannot be estimated from the
available data)
Increased salivation
Vomiting
Increased sensitivity to stimulation, depression,
other nervous signs
*Transient.
In the case of licking the administration site, a brief period of excessive salivation
may be observed due mainly to the nature of the carrier.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the last section of the package leaflet for contact
details.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time. Fleas from pets often infest the animal's
basket, bedding and regular resting areas such as carpets and soft furnishings which
should be treated, in case of massive infestation and at the beginning of the control
measures, with a suitable insecticide and vacuumed regularly.
Bathing and/or shampooing should be avoided. No information on the effect of
bathing or the use of a shampoo on the effectiveness of the product in cats is
available. Based on information available for dogs, bathing/immersion in water within
2 days after application of the product and more frequent bathing than once a week
should be avoided.

i) Special precautions for use in animals
For external use only. Do not administer orally.
Avoid contact with the animal’s eyes. If the product is in contact with eyes, rinse
immediately with plenty of water.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment. Do not apply the product on wounds or skin lesions.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
For use during pregnancy, see section 4.7.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.

Revised: January 2025
AN: 03104/2023
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product. Avoid contents coming into contact with the fingers. If this
occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with clean water.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet to the physician.
Wash hands after use.
Do not smoke, drink or eat during application.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Keep pipettes in original packaging until ready to use.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
This veterinary medicinal product does not require any special temperature storage
conditions. Store in the original package in order to protect from light and moisture.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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