POM-V Prescription Required

Karidox Doxycycline 500 mg/g Powder for use in Drinking Water for Pigs, Chickens and Turkeys

Active ingredient: Doxycycline

Form

Powder

Species

Chickens Pigs Turkeys

Manufacturer

Laboratorios Karizoo S.A

VMD MA No.

31223/4001

What it's used for

Chicken and turkey: treatment of clinical respiratory infections associated with Mycoplasma gallisepticum susceptible to doxycycline.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline

1

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2

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Prescription required

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Clinical information

Karidox Doxycycline 500 mg/g Powder for use in Drinking Water for Pigs, Chickens and Turkeys — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chicken and turkey: treatment of clinical respiratory infections associated with
Mycoplasma gallisepticum susceptible to doxycycline.

In pigs and chicken, 23.1 mg doxycycline hyclate per kg of body weight daily
(equivalent to 40.0 mg of veterinary medicinal product per kg of body weight),
administered in the drinking water for 5 consecutive days.
In turkeys, 28.8 mg doxycycline hyclate per kg of body weight daily (equivalent to 50.0
mg of veterinary medicinal product per kg of body weight), administered in the drinking
water for 5 consecutive days.
Based on the recommended dose, and the number and weight of the animals to be
treated, the exact daily amount of the veterinary medicinal product should be
calculated according to the following formula:
AN: 03307/2024 and 03311/2024
mg veterinary medicinal product
/ kg body weight per day
x Average body weight (kg) of
animals to be treated
Average daily water intake (l) per animal= .... mg
veterinary
medicinal
product per
litre drinking
water
To ensure a correct dosage body weight should be determined as accurately as
possible. The intake of medicated water is dependent on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration in drinking water may
need to be adjusted accordingly.
The use of suitably calibrated weighing equipment is recommended. The daily amount
is to be added to the drinking water such that all medication will be consumed in 24
hours. It is recommended to prepare a concentrated pre-solution and to dilute this
further to therapeutic concentrations if required. Alternatively, the concentrated
solution can be used in a proportional water medicator.
Medicated water should be refreshed every 24 hours. The medicated water should be
the only source of drinking water, throughout the treatment period. The medicated
water must not be prepared or stored in a metal container.
The maximum solubility of the product in water is 72 g/l. Solubility of the product is pH
dependent and it will precipitate if it is mixed in an alkaline solution.

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with hepatic dysfunction.
AN: 03307/2024 and 03311/2024

Pigs, chickens and turkeys.
Rare
(1 to 10 animals / 10,000 animals treated):
Allergic reaction
Photosensititivy
1
If suspected adverse reactions occur, treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of drinking water, animals should be treated parenterally.
Under-dosing and/or treating for an insufficient length of time are considered to
promote the development of resistance in bacteria and should be avoided.

Special precautions for safe use in the target species:
Inappropriate use of the product may increase the prevalence of bacteria resistant to
tetracycline due to the potential for cross resistance.
Use of the product should be based on susceptibility testing of the bacteria isolated
from the animal. If this is not possible, therapy should be based on local (regional,
farm level) epidemiological information about susceptibility of the target bacteria.
The safety of the product has not been established in piglets before weaning.
Avoid administration in oxidised drinking equipment.
Do not use when tetracycline resistance has been detected in the herd/flock due to the
potential for cross resistance.
Due to the likely variability (time, geographical) in the occurrence of resistance of
bacteria for doxycycline, bacteriological sampling and susceptibility testing are
recommended.
A high resistance rate of E. coli, isolated from chickens, against tetracyclines has been
documented. Therefore the veterinary medicinal product should be used for the
treatment of infections caused by E. coli only after susceptibility testing has been
carried out.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene, proper
ventilation, no overstocking.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to tetracyclines should avoid contact with the
veterinary medicinal product.
During preparation and administration direct contact of the veterinary medicinal
product with the skin, eyes and mucous membranes and inhalation of dust particles
should be avoided.
Personal protective equipment consisting of protective gloves (e.g. rubber or latex),
goggles and an appropriate dust mask (either a disposable half-mask respirator
conforming to European Standard EN 149 or a non-disposable respirator to European
Standard EN 140 with a filter to EN 143) should be worn when handling the veterinary
medicinal product. Wash exposed skin after preparation. In case of accidental contact
with the eyes, rinse abundantly with water. Do not smoke, eat or drink when handling
the product.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician. Inflammation of the face, lips or eyes or
respiratory difficulties are the most serious signs which require urgent medical
attention.
AN: 03307/2024 and 03311/2024
Special precautions for the protection of the environment:
Not applicable.

Do not administer concurrently with feed overloaded with polyvalent cations such as
Ca
2+
, Mg
2+
, Zn
2+
and Fe
3+
because the formation of doxycycline complexes with these
cations is possible. It is advised that the interval between administration of other
products containing polyvalent cations should be 1-2 hours because they limit the
absorption of tetracycline.
Do not administer together with antacids, kaolin or iron preparations.
Do not administer in conjunction with bactericidal antibiotics such as beta-lactams as
tetracyclines are bacteriostatic antimicrobials.
Doxycycline increases the action of anticoagulants.

Do not store above 25ºC.

Pigs:Meat and offal:4 daysChickens:Meat and offal:5 daysTurkeys:Meat and offal:12 days
Not for use in birds producing or intended to produce eggs for human consumption.
AN: 03307/2024 and 03311/2024

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.