Doxipulvis 500 mg/g Powder for Use in Drinking Water / Milk

Calves, pigs:
10 mg of doxycycline per kg of body weight per day (equivalent to 11.54 mg of
doxycycline hyclate/kg bw /day) by oral route, during 3 to 5 days, or 0.2 g of powder
per 10 kg of body weight per day, during 3-5 consecutive days, to be dissolved in
drinking water, milk or liquid feed; to be adjusted according to actual feed intake of
the animals, in order to meet the weight dosage.
Chickens and turkeys:
10 mg of doxycycline per kg of body weight per day (equivalent to 11.54 mg of
doxycycline hyclate/kg bw /day), equivalent to 0.02 g of soluble powder per kg of
body weight during 3 to 5 consecutive days, to be dissolved in drinking water.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
0.02 g of powder body weight (kg)
per kg of body X of the animals to be
weight per day treated
-------------------------------------------------------- = … g of powder per litre
Average water intake per animal (litres) of drinking water
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The intake of medicated feed or water depends on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration of doxycycline may
need to be adjusted accordingly.
The use of suitably calibrated weighing equipment for the administration of the
calculated amount of product is recommended.
The daily amount of powder should be added to the drinking water so that the drug is
consumed in 24 hours divided in two administrations. Drinking water containing the
drug substance has to be freshly prepared every 12 hours. It is recommended to
prepare a concentrated solution (approximately 10 g of product per litre of water)
which can be diluted later, if necessary, to the therapeutic concentration. It is also
possible to distribute the concentrated solution using a metering pump.
AN: 01172/2025Page 5 of 8
The product should not be prepared at a concentration below 0.1 g of powder/L of
hard water/ milk and at pH above 8.2.
The solubility of the product has been tested at the maximum concentration of 400
g/L.
The medicated water should be the only source of drinking water, throughout the
treatment period. Water uptake should be monitored at frequent intervals during
medication.
Sufficient access to the system of water supply should be available for the animals to
be treated to ensure adequate water consumption. The medicated water must not be
prepared or stored in a metal container. After the end of the medication period, the
water supply system should be cleaned appropriately to avoid intake of sub-
therapeutic amounts of the active substance.
The temperature of the milk replacer should not be above 38ºC prior to the
introduction of the finished product.
The milk replacer should be prepared no more than one hour prior to the addition of
the product and the medicated milk replacer should be used immediately.
When administering in liquid feed, first dissolve the product in water and then add
feed. The preparation should be used immediately. Care should be taken that the
intended dose will be completely ingested.