Doxybactin 400 mg Tablets for Dogs

None.
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Special precautions for safe use in the target species:
The veterinary medicinal product should be administered with caution to animals with
dysphagia or diseases accompanied with vomiting, since administration of
doxycycline hyclate tablets has been associated with oesophageal erosion.
In order to reduce the likelihood of oesophageal irritation as well as other
gastrointestinal side effects, the veterinary medicinal product should be administered
together with food.
Special care should be taken when administering the veterinary medicinal product to
animals with liver disease, since increases in hepatic enzymes have been
documented in some animals after doxycycline treatment.
The veterinary medicinal product should be administered with caution to young
animals, since tetracyclines as a class may cause permanent discolouration of the
teeth, when administered during tooth development. However, human literature
indicates that doxycycline is less likely than other tetracyclines to cause these
abnormalities, due to its reduced ability to chelate calcium.
Use of the veterinary medicinal product should be based on identification and
susceptibility testing of the target pathogens. If this is not possible, therapy should be
based on epidemiological information and knowledge of susceptibility of the target
pathogens at local / regional level. Use of the veterinary medicinal product should be
in accordance with official, national and regional antimicrobial policies. Use of the
veterinary medicinal product deviating from the instructions given in the SPC may
increase the prevalence of bacteria resistant to doxycycline and may decrease the
effectiveness of treatment with other tetracyclines, due to the potential for cross-
resistance.
As tablets are flavoured store tablets out of reach of the animals in order to avoid
accidental ingestion.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Tetracyclines may cause hypersensitivity (allergy) reactions.
People with known hypersensitivity to tetracyclines should avoid contact with the
veterinary medicinal product.
If you develop symptoms following exposure such as skin rash, seek medical advice
immediately and show the package leaflet to the physician.
Doxycycline may cause gastrointestinal disturbances after accidental ingestion,
especially by children. To avoid accidental ingestion, particularly by a child, unused
tablet parts should be returned to the open blister space and inserted back into the
carton. In case of accidental ingestion, particularly by children, seek medical advice
immediately and show the package leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
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