POM-V Prescription Required

Karidox 100 mg/ml Solution for Use in Drinking Water for Chickens and Pigs

Active ingredient: Doxycycline

Form

Liquid

Species

Chickens Pigs

Manufacturer

Laboratorios Karizoo S.A

VMD MA No.

31223/4000

What it's used for

PIGS Metaphylaxis and treatment of clinical respiratory disease due to Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to doxycycline. The pre...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline

1

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2

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Prescription required

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Clinical information

Karidox 100 mg/ml Solution for Use in Drinking Water for Chickens and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

PIGS
Metaphylaxis and treatment of clinical respiratory disease due to Pasteurella
multocida and Mycoplasma hyopneumoniae sensitive to doxycycline.
The presence of the disease in the herd should be established before the
metaphylactic treatment.

corresponding to 0.1 – 0.2 ml of the veterinary medicinal product per kg body
weight, for 3-5 consecutive days
PIGS: 11.5 mg doxycycline hyclate/ kg body weight / day, corresponding to 0.1
ml of the veterinary medicinal product per kg body weight, for 5 consecutive
days).
Based on the recommended dose, and the number and weight of the animals to
be treated, the exact daily amount of the veterinary product should be
calculated according to the following formula:
X ml veterinary
medicinal product/
kg body
weight/day
x
Average body
weight (kg) of
animals to be
treated
=
X ml
veterinary
medicinal
product per
litre of
drinking water
Average daily water intake (l/animal)
To ensure a correct dosage body weight should be determined as accurately as
possible. The intake of medicated water depends on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration of doxycycline
in drinking water may need to be adjusted accordingly.
The use of suitably calibrated measuring equipment is recommended if part
packs are used. The daily amount is to be added to the drinking water such that
all medication will be consumed in 24 hours. Medicated drinking water should
be freshly prepared every 24 hours. It is recommended to prepare a
concentrated pre-solution – approximately 100 grams product per litre drinking
water – and to dilute this further to therapeutic concentrations if required.
Alternatively, the concentrated solution can be used in a proportional water
medicator.
Medicated water should be the only drinking source.
The remaining medicated water should be disposed of in accordance with local
requirements.
If no improvement in clinical signs is seen within the treatment duration, the
diagnosis should be reviewed and treatment changed.

Do not use in case of hypersensitivity to tetracyclines.
Do not use in case of resistance to tetracyclines occurs.
Do not use in animals with hepatic dysfunction.
AN: 04110/2024 & 04114/2024

Chickens (broilers) and pigs.
Undetermined frequency
(cannot be estimated from the
available data):
Allergic reaction
photosensitivity
Disorder of gastrointestinal flora
1,2
Digestive disturbance
1,2
If suspected adverse reactions occur, treatment should be discontinued.
In very prolonged treatments.
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See the package leaflet for respective contact details.

Sick animals may have a reduced appetite and altered drinking patterns and
should, if necessary, be medicated parenterally.
In cases of altered food or drinking water uptake, the concentrations should be
adjusted in such a way that the recommended dosage is achieved.
Do not administer to laying hens.

Special precautions for safe use in the target species:
Prolonged or repeated use of this veterinary medicinal product is discouraged.
Attention should be paid to avoidance of stressful conditions and improvement
of management practices and hygiene standards.
Avoid administration in oxidised drinking equipment.
Use of the product should be based on susceptibility testing of the bacteria
isolated from the animal. If this is not possible, therapy should be based on local
(regional and farm level) epidemiological information about susceptibility of the
target bacteria, taking into account official national antimicrobial policies.
Inappropriate use of the product may increase the prevalence of bacteria
resistant to doxycycline and may decrease the effectiveness of treatment with
tetracyclines, due to the potential for cross-resistance.
Due to variability (time, geographical) in susceptibility of bacteria for
doxycycline, bacteriological sampling and susceptibility testing of micro-
organisms from diseased birds on farm are highly recommended.
A high resistance rate of E.coli, isolated from chickens, against tetracyclines
has been documented. Therefore the product should be used for the treatment
of infections caused by E.coli only after susceptibility testing has been carried
out.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene,
proper ventilation, no overstocking.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Tetracyclines may – in very rare cases – induce photosensitivity and allergic
reactions.
People with known hypersensitivity to doxycycline should avoid contact with the
veterinary medicinal product. Personal protective equipment consisting of
gloves, work overall, safety glasses should be worn when handling the
veterinary medicinal product. This veterinary medicinal product is acid and
likely to be irritant. The veterinary medicinal product can be harmful by skin
contact and inhalation and may cause eye irritation. Avoid contact with skin and
eyes. In case of contact with skin, rinse immediately with plenty of water. In
AN: 04110/2024 & 04114/2024
case of contact with eyes, rinse immediately with copious amounts of water and
seek medical advice.
Do not smoke, eat or drink while handling this veterinary medicinal product.
In case of accidental ingestion seek medical advice and show the package
leaflet or the label to the physician.
If any symptom should appear, such as a cutaneous eruption, seek prompt
medical advice. Swelling of the face, lips or eyes or respiratory difficulties are
the most serious signs which require urgent medical attention.
Special precautions for the protection of the environment:
Not applicable.

interaction
Doxycycline absorption may be reduced by the presence of high quantities of
calcium, iron, magnesium or aluminium in the diet. Do not administer together
with antacids, kaolin and iron preparations.
Do not administer together with bactericidal antibiotics.
The solubility of the product is pH dependent and will precipitate if mixed in
alkaline solution
Do not administer with milk replacers
AN: 04110/2024 & 04114/2024

Do not store above 30 C.
Protect from light.

Meat & offal:
Chickens (broilers): 7 days
Pigs: 7 days.
Eggs: Not for use in birds producing or intended to produce eggs for human
consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.