Juramate 250 µg/ml Solution for Injection

CATTLE
(Single or repeated 2mL doses (equivalent to 500 µg. of cloprostenol) by
intramuscular injection).
Therapeutic indications
Sub-oestrus (or non-detected oestrus)
After diagnosing the presence of a corpus luteum – by rectal palpation – treat
with the product and inseminate those animals showing heat. Those animals
which do not show heat to be re-examined 11 days later and may receive a
second injection and be bred at oestrus or at fixed times; once at 72-84 hours or
twice at 72 and 96 hours.
Induction of parturition
Induces parturition in the period around normal term. Induction should take
place as close to the predicted calving date as possible and not more than 10
days before. Induction should not be attempted before day 270 of gestation
measured from the confirmed day of conception, except in pathological
conditions. All treated animals must receive adequate supervision. In common
with other methods of shortening the gestation period a higher than usual
incidence of retention of the foetal membranes is to be expected.
Termination of normal pregnancy
Normal pregnancy can be terminated in cattle from one week after conception
until the 150
th
day of gestation. Best results are obtained during the first 100
days. Treated animals should be kept under observation until expulsion of the
foetus and placenta is complete.
Termination of abnormal pregnancy
Mummified foetus – induction of luteolysis at any stage of pregnancy will result
in the expulsion of the mummified foetus from the uterus into the vagina from
which manual removal may be necessary. Normal cyclical activity should then
follow.
Hydrops of the foetal membrane – Pathological accumulation of placental fluids
can cause severe physiological complications and death. Surgical drainage is
not usually successful in alleviating the condition. In such cases, a single dose
may be used to induce parturition.
Chronic endometritis (Pyometra)
Treat with a single dose. In long-standing cases treatment may be repeated
after 10-14 days.

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Ovarian luteal cysts
Where cystic ovaries associated with persistent luteal tissue and absence of
heat are diagnosed, the product has proved to be effective in correcting the
condition and bringing about a return to cyclicity.
Other indications:
Controlled breeding
Examples of programmes which have been used are:
i) A single treatment of cattle with palpable evidence of a corpus
luteum, followed by breeding on detection of the subsequent
oestrus.
ii) Detection of oestrus for 6 days, breeding those animals seen in
heat; a single treatment is given to all non-served animals on the
th
day and these cattle are bred at subsequent oestrus.
iii) Two injections 11 days apart, breeding at oestrus or at fixed times
(see below).
iv) As iii) above, but breeding any animals showing oestrus before the
second injection. Thus the second dose is given only to those
cattle not seen in oestrus during that time and is followed by
breeding either on signs of oestrus or at fixed times (see below).
Cattle which respond to a single prostaglandin injection will
normally do so within 6 days of treatment. The response time after
two injections is more rapid. Animals may be inseminated on
detection of oestrus in any of the breeding programmes. However,
fixed time insemination should only be used following the second
of a two injection programme (i.e. examples iii) and iv)). In the
latter case insemination should be performed either once at 72-84
hours or twice at 72 and 96 hours after the second injection, as
preferred.
Double ‘fixed-time’ insemination may give superior results to a
single insemination. However, economic factors in the particular
herd may outweigh such a benefit.
For successful treatment, animals should be cycling normally.
Rectal examination before treatment should avoid the
disappointment of treating non-cycling (an-oestrus) or pregnant
animals.
Attention should be directed to the diet and condition of the treated
animals. Sudden changes in feeding levels, in feed constituents
and in housing, etc should be avoided around the time of the
breeding programme, as should any other factor, such as
regrouping, which could reasonably be expected to lead to stress.
If artificial insemination is to be used, the quality of semen and
insemination technique should be assured beforehand.
A recommended guideline for use of the product in dairy cows would be
as follows:
After the first injection, inseminate any cows showing signs of heat.

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Animals that do not show signs of heat should be injected 11 days after
the first injection and then inseminated 72-96 hours later.
Control of the oestrous cycle is of value in:-
1) The dairy herd:
a) To control oestrus in the individual animal giving better
control of the individual calving index and reducing the
number of cows culled as barren.
b) To control oestrus in groups of cows to promote
management of the herd in groups of suitable size and
facilitate the maintenance of a seasonal calving pattern.
c) To permit the use of artificial insemination (AI) in dairy
heifers.
2) The beef herd:
a) To facilitate the use of AI to obtain better progeny by use of
high quality bulls.
b) To enable the most effective use of available bulls where
natural service is preferred.
c) To permit better herd management at conception and
calving.
HORSES
Ponies and donkeys: single dose of 0.5-1.0 ml (equivalent to 125-250 µg
of cloprostenol) by intramuscular injection. Thoroughbreds, hunters and
heavy horses:
1-2 mL (equivalent to 250-500 µg of cloprostenol) by intramuscular
injection).
Induction of luteolysis following early foetal death and resorption: about 8-
10% of all mares which conceive lose the conceptus during the first 100
days of pregnancy. Persistence of luteal function in the ovary precludes
an early return to oestrus.
Termination of persistent dioestrus : non-pregnant mares frequently and
spontaneously go to and out of periods of prolonged dioestrus. A very
high proportion of mares in this category i.e. not cycling, are in prolonged
dioestrus rather than anoestrus, particularly in the latter part of the
breeding season.
Termination of pseudopregnancy: some mares which are covered at
normal oestrus and subsequently found to be empty (but not having lost
or resorbed a conceptus) display clinical signs of pregnancy. These
animals are said to be “pseudopregnant”.
Treatment of lactation anoestrus: failure of lactating mares to cycle again
for several months after exhibiting an early ‘foal heat’ can be avoided.
Establishing oestrous cycles in barren/maiden mares: some of these
animals will be found, on examination, to have a functional corpus luteum
and are suffering from abnormal persistence of luteal function or are

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simply failing to exhibit normal oestrous behaviour (“silent heat”) while
ovarian cyclicity continues.
As an aid in stud management: mares may be brought into oestrus on a
planning timing schedule (singly or in groups), to facilitate more efficient
use and management of stallions during the breeding season.