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AVM-GSL Over the Counter Companion Animal

Frontline Plus Spot-on Dog XL

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Boehringer Ingelheim Vetmedica GmbH

VMD MA No.

04491/3052

What it's used for

For the treatment of dogs weighing over 40 kg bodyweight - To be used against infestations with fleas, alone or in association with ticks and/or biting lic...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Clinical information

Frontline Plus Spot-on Dog XL — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of dogs weighing over 40 kg bodyweight
- To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persist for 8 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae
(larvicidal activity) originating from eggs laid by adult fleas for eight weeks after
application.
- Treatment of tick infestations (Ixodes ,
reticulatus, ) The product has a persistent acaricidal
efficacy for up to 4 weeks against ticks.
- Treatment of infestations with biting lice (Trichodectes canis

Revised: October 2025
AN: 01882/2025
One pipette of 4.02 ml (XL) per dog weighing over 40 kg, corresponding to a
minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-
methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
In the absence of available data, the product should not be used on puppies less
than 8 weeks old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur.
absence of studies, the use of the product is not recommended in non-target species.
This product is specifically developed for dogs. Do not use in cats and ferrets, as this
could lead to overdosing.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (skin discoloration, local hair loss, itching, redness) and general
itching or hair loss have been reported after use. Excessive salivation, reversible
nervous signs (increased sensitivity to stimulation, depression, other nervous signs),
vomiting or respiratory symptoms have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier .
Do not overdose.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time.

Special precautions for use in animals
Avoid contact with the animal's eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Animals should be weighed accurately prior to treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep pipettes in original packaging until ready to use. In order to prevent children
from getting access to used pipettes, dispose of used pipettes immediately.
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet to the physician.

Revised: October 2025
AN: 01882/2025
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product. Avoid contents coming into contact with the fingers. If this
occurs, wash hands with soap and water.
After accidental exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Other Precautions
Fipronil and (S) methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in watercourses for 2 days after application.
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
Do not use simultaneously with other flea products which are applied directly on to
the animal.

Revised: October 2025
AN: 01882/2025
Do not store above 30°C. Store in the original package.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

Price comparison

Frontline Plus Spot-on Dog XL Prices by Online retailer

Price Comparison

VetMedi
£16.99
Trustpilot: 4.9/5 (3,295 reviews) · 3
In stock
VetUK
£17.49
Trustpilot: 4.0/5 (25,586 reviews) · 3
In stock
Animed Direct
£17.99
Trustpilot: 4.6/5 (354,000 reviews) · 3
In stock
Pet Drugs Online
£19.49
Trustpilot: 2.5/5 (500 reviews) · 3
In stock

Prices last checked: 7 months ago. Prices may vary. Always confirm with the online retailer before ordering.

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