AVM-GSL
Over the Counter
Companion Animal
Frontline Plus Spot-on Cat
Active ingredients: (S)-Methoprene, Fipronil
Form
Spot-on
Species
Cats
Ferrets
Manufacturer
Boehringer Ingelheim Vetmedica GmbH
VMD MA No.
04491/3056
What it's used for
In cats: To be used against infestations with fleas, alone or in association with ticks and/or biting lice. - Treatment of flea infestations (Ctenocephalid...
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£7.99
from The Pharm Pet Co
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Clinical information
Frontline Plus Spot-on Cat — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
In cats:
To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six
weeks after application.
- Treatment of tick infestations (Ixodes , ,
Rhipicephalus ). The product has a persistent acaricidal efficacy for up
to 2 weeks against ticks (based on experimental data).
-Felicola subrostratus).
In ferrets:
To be used against infestations with fleas, alone or in association with ticks.
Revised: October 2025
AN: 01892/2025
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.
- Treatment of tick infestations (Ixodes ). The product has a persistent
acaricidal efficacy for 4 weeks against ticks (based on experimental data).
To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six
weeks after application.
- Treatment of tick infestations (Ixodes , ,
Rhipicephalus ). The product has a persistent acaricidal efficacy for up
to 2 weeks against ticks (based on experimental data).
-Felicola subrostratus).
In ferrets:
To be used against infestations with fleas, alone or in association with ticks.
Revised: October 2025
AN: 01892/2025
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against
new infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.
- Treatment of tick infestations (Ixodes ). The product has a persistent
acaricidal efficacy for 4 weeks against ticks (based on experimental data).
For external use only – Spot-on application.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of
5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60
mg for (S)-methoprene per ferret, by topical application to the skin.
The minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of
5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60
mg for (S)-methoprene per ferret, by topical application to the skin.
The minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
In the absence of available data, the product should not be used on kittens less than
8 weeks old and/or weighing less than 1 kg. The product should not be used on
ferrets less than 6 months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur.
absence of studies, the use of the product is not recommended in non-target species.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
8 weeks old and/or weighing less than 1 kg. The product should not be used on
ferrets less than 6 months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur.
absence of studies, the use of the product is not recommended in non-target species.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Do not overdose.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use. Excessive salivation, reversible nervous signs
(increased sensitivity to stimulation, depression, other nervous signs) or vomiting
have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (scaling, local hair loss, itching, redness) and general itching or hair
loss have been reported after use. Excessive salivation, reversible nervous signs
(increased sensitivity to stimulation, depression, other nervous signs) or vomiting
have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Avoid contact with the animal’s eyes.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time.
Special precautions for use in animals
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in cats
and ferrets are available. However, based on information available for dogs
shampooed as from 2 days after application of the product, it is not recommended to
bath animals within 2 days after application of the product.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
Animals should be weighed accurately prior to treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep pipettes in original packaging until ready to use. In order to prevent children
from getting access to used pipettes, dispose of used pipettes immediately.
Revised: October 2025
AN: 01892/2025
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet to the physician.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product. Avoid contents coming into contact with the fingers. If this
occurs, wash hands with soap and water.
After accidental exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Other Precautions
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate product at the same time.
Special precautions for use in animals
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in cats
and ferrets are available. However, based on information available for dogs
shampooed as from 2 days after application of the product, it is not recommended to
bath animals within 2 days after application of the product.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact
with a treated queen is not documented. Special care should be taken in this case.
Animals should be weighed accurately prior to treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Keep pipettes in original packaging until ready to use. In order to prevent children
from getting access to used pipettes, dispose of used pipettes immediately.
Revised: October 2025
AN: 01892/2025
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided.
If the product is accidentally swallowed, seek medical advice immediately and show
the package leaflet to the physician.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product. Avoid contents coming into contact with the fingers. If this
occurs, wash hands with soap and water.
After accidental exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Other Precautions
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
the animal.
Do not store above 25°C
Store in the original package.
Store in the original package.
Ferrets
Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic
or maternotoxic effects. The safety of the veterinary medicinal product has not been
established in ferrets during pregnancy and lactation. Use only according to the risk-
benefit assessment by the responsible veterinarian.
Revised: October 2025
AN: 01892/2025
4.8 Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with other flea products which are applied directly on to
the animal.
4.9 Amounts to be administered and administration route
For external use only – Spot-on application.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of
5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60
mg for (S)-methoprene per ferret, by topical application to the skin.
The minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of experiencing adverse effects may increase with overdosing (see section
4.6).
In cats
No undesirable effects were observed in target animal safety studies in cats and
kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five
times the recommended dose for six consecutive months.
Itching may occur following treatment.
Overdose application of the product will cause a sticky appearance of hairs at the
treatment spot. However, should this occur, it will disappear within 24 hours post
application.
In ferrets
In ferrets aged 6 months and older and treated once every 2 weeks for four
treatments, at five times the recommended dose, body weight loss was observed in
some animals.
4.11 Withdrawal period(s)
Not applicable.
5.
Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic
or maternotoxic effects. The safety of the veterinary medicinal product has not been
established in ferrets during pregnancy and lactation. Use only according to the risk-
benefit assessment by the responsible veterinarian.
Revised: October 2025
AN: 01892/2025
4.8 Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with other flea products which are applied directly on to
the animal.
4.9 Amounts to be administered and administration route
For external use only – Spot-on application.
One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of
5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60
mg for (S)-methoprene per ferret, by topical application to the skin.
The minimum treatment interval is 4 weeks.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of experiencing adverse effects may increase with overdosing (see section
4.6).
In cats
No undesirable effects were observed in target animal safety studies in cats and
kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five
times the recommended dose for six consecutive months.
Itching may occur following treatment.
Overdose application of the product will cause a sticky appearance of hairs at the
treatment spot. However, should this occur, it will disappear within 24 hours post
application.
In ferrets
In ferrets aged 6 months and older and treated once every 2 weeks for four
treatments, at five times the recommended dose, body weight loss was observed in
some animals.
4.11 Withdrawal period(s)
Not applicable.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
Price comparison
Frontline Plus Spot-on Cat Prices by Online retailer
Price Comparison
The Pharm Pet Co
£7.99
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£14.99
Trustpilot: 4.9/5 (3,295 reviews)
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VetUK
£15.49
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Animed Direct
£15.99
Trustpilot: 4.6/5 (354,000 reviews)
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Pet Drugs Online
£17.49
Trustpilot: 2.5/5 (500 reviews)
· 3
In stock
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