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POM-V Prescription Required Companion Animal

Frontline Combo 50.00 mg / 60.00 mg Spot-on Solution for Cat

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Cats Ferrets

Manufacturer

Boehringer Ingelheim Vetmedica GmbH

VMD MA No.

61700/3017

What it's used for

- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the mult...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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  1. 1

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Frontline Combo 50.00 mg / 60.00 mg Spot-on Solution for Cat — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity), larvae and
pupae (larvicidal activity) originating from eggs laid by adult fleas for six weeks
after application.
- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus
sanguineus). The veterinary medicinal product has a persistent acaricidal
efficacy for up to 2 weeks against ticks (based on experimental data).
- Elimination of biting lice (Felicola subrostratus).
The veterinary medicinal product can be used as part of a treatment strategy for the
control of Flea Allergy Dermatitis (FAD).
In ferrets:
To be used against infestations with fleas, alone or in association with ticks.
- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new
infestations with adult fleas persists for 4 weeks. Prevention of the multiplication
of fleas by inhibiting the development of eggs (ovicidal activity), larvae and
pupae (larvicidal activity) originating from eggs laid by adult fleas.
- Elimination of ticks (Ixodes ricinus). The veterinary medicinal product has a
persistent acaricidal efficacy for 4 weeks against ticks (based on experimental
data).
Underdosing could result in ineffective use and may favour resistance development.
Cats:
The minimum dose is 5 mg/kg bw of fipronil and 6 mg/kg bw of (S)-methoprene,
corresponding to one pipette of 0.5 ml per cat.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Ferrets:
The dose is 50 mg of fipronil and 60 mg of (S)-methoprene per ferret, corresponding
to one pipette of 0.5 ml per ferret.
The minimum treatment interval is 4 weeks.
For infestations with fleas and/or ticks, the need for and frequency of re-treatment(s)
should be based on professional advice and should take into account the local
epidemiological situation and the animal’s lifestyle.
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Snap back the tip. Part the coat on the
back of the animal at the base of the neck in front of the shoulder blades until the
skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several
times to empty its contents completely and directly onto the skin in one spot.
In the absence of available data, the veterinary medicinal product should not be used
on kittens less than 8 weeks old and/or weighing less than 1 kg. The veterinary
medicinal product should not be used on ferrets less than 6 months old.
Do not use in rabbits, as adverse drug reactions with even mortality could
occur. In absence of studies, the use of the veterinary medicinal product is not
recommended in non-target species.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Cats and Ferrets:
Very rare
(< 1 animal / 10,000 animals treated,
including isolated reports):
Application site reactions (skin scaling
,
hair loss
, itching
, reddening
).
Generalised itching or hair loss.
Hypersalivation
, vomiting.
Increased sensitivity to stimulation
,
depression
, other nervous signs
.
Transient
If licking occurs, a brief period of hypersalivation may be observed due mainly to
the nature of the carrier.
Reversible
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of based on its epidemiological features, for each
individual animal.
No data on the effect of bathing/shampooing on the efficacy of the veterinary
medicinal product in cats and ferrets are available. However, based on information
available for dogs shampooed as from 2 days after application of the veterinary
medicinal product, it is not recommended to bath animals within 2 days after
application of the veterinary medicinal product.
There may be an attachment of single ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
Other animals living in the same household should also be treated with a suitable
product.

Special precautions for safe use in the target species:
Avoid the contact with the animal’s eyes.
It is important to make sure that the veterinary medicinal product is applied to an
area where the animal cannot lick it off and to make sure that animals do not lick
each other following treatment.
The potential toxicity of the veterinary medicinal product for kittens of less than 8
weeks of age in contact with a treated queen is not documented. Special care should
be taken in this case.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal
irritation. Therefore, contact of the veterinary medicinal product with mouth, skin and
eyes should be avoided.
People with a known hypersensitivity to fipronil or (S)-methoprene, or alcohol should
avoid contact with the veterinary medicinal product. Avoid contents coming into
contact with the fingers. If this occurs, wash hands with soap and water.
After accidental exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Special precautions for the protection of the environment:
See section 5.5.
None known.
Do not store above 25°C. Store in the original package.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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