Frontline Combo 268.00 mg / 241.20 mg Spot-on Solution for Dog L

Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of based on its epidemiological features, for each
individual animal.
Bathing/immersion in water within 2 days after application of the veterinary medicinal
product and more frequent bathing than once a week should be avoided, as no study
has been performed to investigate how this affects the efficacy of the veterinary
medicinal product. Emollient shampoos can be used prior to treatment, but reduce
the duration of protection against fleas to approximately 5 weeks when used weekly
after application of the veterinary medicinal product. Weekly bathing with a 2%
chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6
week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
Other animals living in the same household should also be treated with a suitable
product.

Special precautions for safe use in the target species:
Avoid contact with the animal's eyes.
It is important to make sure that the veterinary medicinal product is applied to an
area where the animal cannot lick it off and to make sure that animals do not lick
each other following treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane, skin and eye
irritation. Therefore, contact of the veterinary medicinal product with mouth, skin and
eyes should be avoided.
People with a known hypersensitivity to fipronil or (S)-methoprene, or alcohol should
avoid contact with the veterinary medicinal product. Avoid contents coming into
contact with the fingers. If this occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Do not smoke, drink or eat during application.
Special precautions for the protection of the environment:
Dogs should not be allowed to swim in watercourses for 2 days after application (see
section 5.5).