Fixplan 200 IU/ml Lyophilisate and Solvent for Solution for Injection

Routes of administration: Cattle and sheep: intramuscular use; pigs: intramuscular or
subcutaneous use.
Reconstitution: Reconstitute the lyophilisate with the solvent provided. Dissolve the
lyophilisate with a small quantity of solvent. Mix to obtain a homogenous solution.
Transfer this solution into the vial that contains the rest of the solvent and mix until
completely dissolved.
Ensure the lyophilisate has fully dissolved before use.
Use normal aseptic precautions. Avoid the introduction of contamination.
Female
animals
IndicationDosage and administrationCattleAnoestrus/oestrus induction500 – 1,000 IU (i.e. 2.5 to 5 ml of
product), IM
Superovulation1,500 – 3,000 IU (i.e. 7.5 to 15 ml of
product), IM, between day 8– 13 of
the cycle, followed by prostaglandin,
IM, 48 hours later
Increase in fertility rate after
progestagen pre-treatment
300 – 750 IU (i.e. 1.5 to 3.75 ml of
product), IM at the end of a
progestagen treatment
SheepIncrease in fertility rate after
progestagen pre-treatment (in
and out of breeding season)
400 - 750 IU (i.e. 2.0 to 3.75 ml of
product), IM, at time of progestagen
removal
PigAnoestrus post-weaning
(induction of oestrus is difficult
until 40 days post partum)
1000 IU (i.e. 5 ml of product), SC, or
IM, fertile oestrus usually follows
within 3 – 7 days
Anoestrus is often caused by inadequate management (feeding and housing).
Improvement of management is therefore a prerequisite for a successful treatment.
Equine serum gonadotropin is a protein hormone which acts on the ovary to
stimulate the production of follicles. The number of follicles produced can be
influenced by the dose of equine serum gonadotropin administered and this must be
taken into account when, for instance, calculating the dose for a particular flock of
ewes in which oestrus synchronisation is desired. In general, the further out of
season that breeding is attempted and the lower the normal prolificacy of the flock,
the more equine serum gonadotropin that will be required.
An average dose of 500 IU / ewe is recommended as a useful starting point but
doses ranging from 400 - 750 IU have been used on occasion. It is therefore
recommended that accurate flock records are kept of breed, dose given, time of
injection and lambs produced so that in future seasons the amount can, if necessary,
be adjusted for optimum results.

Revised: March 2025
AN: 03511/2024 + 03815/2024Page 4 of 7
Superovulation in cattle
The veterinary medicinal product may be used for the superovulation of female donor
cattle prior to embryo transfer.
The following is an example, of a regime that has been successfully been applied in
the field:
•
between day 8 and 13 of a normal oestrus cycle. NB: the exact dose of the
veterinary medicinal product required to achieve effective superovulation will
depend upon a number of factors particularly the breed, age, reproductive
history, general health and nutritional status of the donor female and is subject
to individual variation.
•
inducedby the injection of a prostaglandin analogue. Usually 1 ½ times the
normal luteolytic dose is administered. Oestrus normally occurs approximately
48 hours after the prostaglandin injection.
•
•
insemination. Suitable embryos are transferred to female recipient cattle
whose oestrus cycles have previously been synchronised with that of the
donor female. Experience has shown that oestrus cycles in donor and
recipient females should be synchronised within ± 24 hours if reasonable
success is to be expected.
•
should be administered at the time of embryo collection.
Note:
1. Despite the application of a suitable treatment regime certain individual donor
cows may fail to respond.
2. Wide variations in response may be expected between individual animals.
Repeated treatment of a single animal may also yield variable results.
3. The overall success of an embryo transfer protocol will be influenced by the
availability of suitable equipment and the skill and experience of the operator.