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AVM-GSL Over the Counter Companion Animal

Fiprotec Combo 50 mg/ 60 mg Spot-on Solution for Cats

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Cats

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/4122

What it's used for

against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal a...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Fiprotec Combo 50 mg/ 60 mg Spot-on Solution for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

against new infestations with adult fleas persists for 4 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity),
larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for
six weeks after application.
-Ixodes ricinus, Dermacentor variabilis,
Rhipicephalus sanguineus). The veterinary medicinal product has a persistent
acaricidal efficacy for up to 2 weeks against ticks (based on experimental data).
AN: 03064/2024 and 03049/2024Page 2 of 7
-Felicola subrostratus).
One pipette of 0.5 ml per cat weighing at least 1 kg corresponding to a minimum
recommended dose of 5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical
application to the skin.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette.
Push and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the back of the animal at the base of the neck in front of the
shoulder blades until the skin is visible. Place the tip of the pipette onto the skin
and squeeze the pipette several times to empty its contents completely and
directly onto the skin in one spot.
In the absence of available data, the veterinary medicinal product should not be used
on kittens less than 8 weeks old and/or weighing less than 1 kg.
Do not use in sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Do not apply on wounds or damaged skin.
Do not use in rabbits, as adverse drug reactions with even mortality could
occur.
Do not use in any other non-target species.
Cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site skin scaling
, Application site hair
loss
, Application site itching
, Application site
reddening
Generalised itching, General hair loss
Hypersalivation
, Vomiting
Neurological signs
, Hyperaesthesia
Depression
1
Transient
May be observed briefly in the case of licking the administration site, also (mainly
due to the nature of the carrier)
Reversible
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
When treating infestations of parasites, all in-contact animals should be treated with
an appropriate veterinary medicinal product at the same time. Fleas from pets often
infest the animal's basket, bedding and regular resting areas such as carpets and
soft furnishings which should be treated, in case of massive infestation and at the
beginning of the control measures, with a suitable insecticide and vacuumed
regularly.
Bathing and/or shampooing should be avoided. No information on the effect of
bathing or the use of a shampoo on the effectiveness of the veterinary medicinal
product in cats is available. Based on information available for dogs,
bathing/immersion in water within 2 days after application of the veterinary medicinal
product and more frequent bathing than once a week should be avoided.
There may be an attachment of single ticks. For this reason, a transmission of
infectious diseases cannot be completely excluded if conditions are unfavourable.

Special precautions for safe use in the target species:
Avoid contact with the animal’s eyes.
It is important to make sure that the veterinary medicinal product is applied to an area
where the animal cannot lick it off and to make sure that animals do not lick each
other following treatment.
Do not overdose.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane, skin and eye
irritation. Therefore, contact of the veterinary medicinal product with mouth, skin and
eyes should be avoided.
People with a known hypersensitivity (allergy) to fipronil, S-methoprene, insecticides
or alcohol should avoid contact with the veterinary medicinal product. Avoid contents
coming into contact with the fingers. If this occurs, wash hands with soap and water.
AN: 03064/2024 and 03049/2024Page 3 of 7
After accidental ocular exposure the eye should be rinsed carefully in clean water.
If the veterinary medicinal product is accidentally swallowed, seek medical advice
immediately and show the package leaflet to the physician.
Wash hands after use.
Do not smoke, drink or eat during application.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Keep pipettes in original packaging until ready to use.
Special precautions for the protection of the environment:
Not applicable.
Do not use simultaneously with other flea products which are applied directly on to
the animal.
Store below 30 C.
Store in the original package in order to protect from light and moisture.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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