Skip to content
NFA-VPS Over the Counter Companion Animal

Fiproclear Combo 67 mg / 60.3 mg Spot-on Solution for Small Dogs

Active ingredients: (S)-Methoprene, Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4408

What it's used for

For the treatment of dogs weighing 2 to 10 kg bodyweight. To be used against infestations with fleas, alone or in association with ticks and/or biting lice...

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for (S)-Methoprene + Fipronil

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Fiproclear Combo 67 mg / 60.3 mg Spot-on Solution for Small Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of dogs weighing 2 to 10 kg bodyweight.
To be used against infestations with fleas, alone or in association with ticks and/or
biting lice.
•Ctenocephalides spp.). Insecticidal efficacy
against new infestations with adult fleas persist for 8 weeks. Prevention of the
multiplication of fleas by inhibiting the development of eggs (ovicidal activity)
and larvae and pupae (larvicidal activity) originating from eggs laid by adult
fleas for eight weeks after application.
•Ixodes ,
Dermacentor reticulatus, ). The product has a
persistent acaricidal efficacy for up to 4 weeks against ticks.

Revised: April 2022
AN: 01219/2021 & 01221/2021Page 2 of 7
•Trichodectes canis).
Dosage: One pipette of 0.67 ml per dog weighing over 2 and up to 10 kg,
corresponding to a minimum recommended dose of 6.7 mg/kg for fipronil and 6
mg/kg for (S)-methoprene.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Route of administration: External use only, spot-on use.
Only remove pipette from sachet immediately prior to use.
Method of Administration:

Revised: April 2022
AN: 01219/2021 & 01221/2021Page 4 of 7
Remove the pipette from the outer sachet using scissors or fold along diagonal line to
expose nick; tear back at nick.
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Twist or snap back the tip.
Part the coat on the back of the animal at the base of the neck in front of the shoulder
blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the
pipette several times to empty its contents completely and directly onto the skin in
one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
In the absence of available data, the product should not be used on puppies less
than 8 weeks old and/or weighing less than 2 kg.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur.
absence of studies, the use of the product is not recommended in non-target species.
This product is specifically developed for dogs. Do not use in cats and ferrets, as this
could lead to overdosing.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Among the very rare suspected adverse reactions, transient skin reactions on the
application site (skin discoloration, local hair loss, itching, redness) and general
itching or hair loss have been reported after use. Excessive salivation, reversible
nervous signs (increased sensitivity to stimulation, depression, other nervous signs),
vomiting or respiratory symptoms have also been observed after use.
The frequency of adverse reactions is defined using the following convention:
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
If licking occurs, a brief period of excessive salivation may be observed due mainly to
the nature of the carrier .
Bathing/immersion in water within 2 days after application of the product and more
frequent bathing than once a week should be avoided, as no study has been
performed to investigate how this affects the efficacy of the product. Emollient
shampoos can be used prior to treatment, but reduce the duration of protection
against fleas to approximately 5 weeks when used weekly after application of the
product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect
efficacy against fleas during a 6 week long study.
There may be an attachment of a few ticks. For this reason a transmission of
infectious diseases cannot be completely excluded if conditions are unfavorable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.

Special precautions for use in animals
Avoid contact with the animal’s eyes.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This product can cause mucous membrane, skin and eye irritation. Therefore,
contact of the product with mouth, skin and eyes should be avoided. Do not smoke,
drink or eat during the application. In case of accidental eye contact, immediately and
thoroughly rinse the eyes with clean water. If eye irritation persists seek medical
advice and show the package leaflet or the label to the physician. If contact with the
skin occurs, wash hands with soap and water.
People with a known hypersensitivity to insecticides or alcohol should avoid contact
with the veterinary medicinal product.

Revised: April 2022
AN: 01219/2021 & 01221/2021Page 3 of 7
Wash hands after use.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product. In case of
accidental ingestion of product, seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Other precautions
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Dogs should
not be allowed to swim in water courses for 2 days after application.
The alcohol carrier may have adverse effects on painted, varnished or other
household surfaces or furnishings.
None known.
Store in the original package in order to protect from light and moisture.
This veterinary medicinal product does not require any special temperature storage
conditions.
Not applicable.

Revised: April 2022
AN: 01219/2021 & 01221/2021Page 5 of 7
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

Medication costs adding up?

Pet insurance can cover prescription medications. Find the right policy for your pet.

Compare insurance

Find cheaper vets near you

Compare vet consultation prices in your area. Save on procedures and get a prescription to buy medications online.