POM-V Prescription Required

Estrumate 250 micrograms/ml Solution for Injection

Active ingredient: Cloprostenol

Form

Injection

Species

Cattle Donkey Goats Horses Pigs

Manufacturer

Intervet International B.V.

VMD MA No.

06376/5057

What it's used for

- - corpus luteum. - - - Goats (does): - Oestrus induction and synchronisation in does with a functional corpus luteum during the breeding season. Horses (...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Cloprostenol

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Estrumate 250 micrograms/ml Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

-
-
corpus luteum.
-
-
-
Goats (does):
- Oestrus induction and synchronisation in does with a functional corpus luteum
during the breeding season.
Horses (mares):
-
-
Donkeys (jennies):
-
Pigs (sows and gilts):
-

Cattle (cows and heifers):
One dose equals 500 micrograms of cloprostenol per animal, corresponding to 2 ml of
the veterinary medicinal product.
Oestrus induction and synchronisation:
Administer one dose per animal. When no oestrus symptoms are observed, a second
dose can be administered after 11 days.
Treatment of clinical and subclinical endometritis in the presence of a functional corpus
luteum.:
Administer one dose per animal. If necessary, repeat the treatment 10-14 days later.
Treatment of ovarian luteal cysts:
Administer a single dose per animal.
Induction of parturition
Administer a single dose per animal, not earlier than 10 days before the expected date
of calving.
Induction of abortion up to day 150 of gestation:
Administer a single dose per animal, between the 5
th
and the 150
th
day of gestation.
Goats (does):
One dose equals 100 – 125 micrograms of cloprostenol per animal, corresponding to
0.4 – 0.5 ml of the veterinary medicinal product.
Oestrus induction:
Administer one dose per animal.
Synchronisation of oestrus:
Administer a second dose per animal 10 – 12 days after the first dose.
Horses (mares):
Ponies and horses weighing less than 500 kg bodyweight:
One dose equals 125 – 250 micrograms of cloprostenol per animal, corresponding to
0.5 – 1 ml of the veterinary medicinal product.
Horses weighing more than 500 kg bodyweight:
One dose equals 250 – 500 micrograms of cloprostenol per animal, corresponding to
1 – 2 ml of the veterinary medicinal product.
Oestrus induction and synchronisation:
Administer a single dose per animal.
Termination of early gestation between day 5 and day 120:
Administer a single dose per animal, not earlier than 5 days after ovulation.
Donkeys (jennies):
One dose equals 125 - 250 micrograms of cloprostenol per animal, corresponding to
0.5 - 1 ml of the veterinary medicinal product, depending upon bodyweight and size.
A lower dose, down to 37.5 micrograms cloprostenol per animal, corresponding to
0.15 ml of the veterinary medicinal product, might be required for small framed jennies
to reduce adverse reactions.
The dose to be applied in general should be as low as possible due to the risk of
adverse events (see section 3.6).
Oestrus induction:
Administer a single dose per animal.
Pigs (sows and gilts):
One dose equals 175 micrograms of cloprostenol per animal, corresponding to 0.7 ml of
the veterinary medicinal product.
Induction of farrowing:
Administer a single dose per animal one or two days before the estimated date of
parturition (see also warnings in section 3.5).
To be administered by deep intramuscular route with a needle at least 4 cm long.
The stopper may be safely punctured up to 10 times. When treating groups of animals
in one run, use a draw-off needle that has been placed in the vial stopper to avoid
excess broaching of the stopper. The draw-off needle should be removed after
treatment.

Do not use in pregnant animals in which the induction of abortion or parturition is not
intended.
Do not administer to induce parturition in animals with suspected dystocia due to
mechanical obstruction or abnormal position, presentation and/or posture of the foetus.
Do not use in animals with compromised cardiovascular function, bronchospasm or
gastrointestinal dysmotility.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.

Cattle (cows and heifers):
Rare
(1 to 10 animals / 10,000
animals treated)
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Abdominal pain
, Diarrhoea
3,5
;
Incoordination
;
Lying down
;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
;
Restlessness, Frequent urination
3,5
;
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic therapy,
particularly covering clostridial species, should be employed at the first sign of infection.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin
muscles.
May be caused by induction of parturition or abortion. As part of induction of
parturition, depending on the date of treatment versus the date of conception, the
incidence of placental retention may be increased.
In case of occurrence, these effects are observed within 15 minutes post-injection and
usually disappear after one hour.
Goats (does):
Rare
(1 to 10 animals / 10,000
animals treated)
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic therapy,
particularly covering clostridial species, should be employed at the first sign of infection.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
Requiring immediate medical attention. Can be life-threatening.
Horses (mares):
Uncommon
(1 to 10 animals / 1,000 animals
treated)
Abnormal oestrus
;Rare
(1 to 10 animals / 10,000
animals treated)
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Increased sweating
4,5
;
Abdominal pain
, Colic
, Diarrhoea
4,8
;
Incoordination
, Muscle tremor
;
Lying down
, Decreased body temperature
;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
;
Restlessness, Frequent urination
4,8
;
Haemorrhagic (anovular) follicles and multiple ovulations are reported in literature for
horses treated with cloprostenol.
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic therapy,
particularly covering clostridial species, should be employed at the first sign of infection.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin
muscles.
Appears to be transient and resolves without any treatment.
Mild.
May be caused by termination of gestation, depending on the date of treatment versus
the date of conception, the incidence of placental retention may be increased.
In case of occurrence, these effects are observed within 15 minutes post-injection and
usually disappear after one hour.
Donkeys (jennies):
Rare
(1 to 10 animals / 10,000
animals treated):
Injection site infection
;Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Increased sweating
3,4
;
Abdominal pain
, Colic
, Diarrhoea
3,7
;
Incoordination
, Muscle tremor
;
Lying down
, Decreased body temperature
,

Anorexia;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
,
Restlessness, Frequent urination
3,7
;
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic therapy,
particularly covering clostridial species, should be employed at the first sign of infection.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin F2α activity in the smooth
muscles.
Appears to be transient and resolves without any treatment.
Mild.
May be caused by induction of parturition or abortion.

As part of induction of
parturition, depending on the date of treatment versus the date of conception, the
incidence of placental retention may be increased.
In case of occurrence, these effects are observed within 15 minutes post-injection and
usually disappear after one hour.
Pigs (sows and gilts):
Rare
(1 to 10 animals / 10,000
animals treated)
Injection site infection
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
;
Increased respiratory rate
;
Increased heart rate
;
Abdominal pain
, Diarrhoea
3,5
;
Incoordination
;
Lying down
;
Retained placenta
, Metritis
, Dystocia
, Stillbirth
;
Restlessness, Frequent urination
3,5
;
May occur if anaerobic bacteria enter the injection site, especially following
intramuscular injection, and may become generalized. Aggressive antibiotic therapy,
particularly covering clostridial species, should be employed at the first sign of infection.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
Requiring immediate medical attention. Can be life-threatening.
Cloprostenol may cause effects similar to Prostaglandin
muscles.
May be caused by induction of parturition. As part of induction of parturition,
depending on the date of treatment versus the date of conception, the incidence of
placental retention may be increased.
In case of occurrence, these effects are observed within 15 minutes post-injection and
usually disappear after one hour.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

There is a refractory period of several days after ovulation (e.g. four to five days in cattle
and horses), when females are insensitive to the luteolytic effect of prostaglandins.
For the termination of gestation in cattle, best results are obtained before day 100 of
gestation. Results are less reliable between day 100 and 150 of gestation.
The response of sows and gilts to induction of parturition may be influenced by the
physiological state and the time of treatment. The vast majority of animals, 95%, will
commence farrowing within 36 hours of treatment. The majority of animals can be
expected to respond within the period of 24+/- 5 hours following the injection, except in
those cases where spontaneous parturition is imminent.

Special precautions for safe use in the target species:
To reduce the risk of anaerobic infections arising from vasoconstriction at the injection
site, injections into contaminated (wet or dirty) skin areas should be avoided.
Thoroughly clean and disinfect injection sites prior to administration.
Do not administer intravenously.
All animals should receive adequate supervision after treatment.
Induction of parturition or abortion may cause dystocia, stillbirth and/or metritis. The
incidence of retained placenta may be increased depending on the time of treatment
relative to the date of conception.
Premature induction of farrowing will reduce the piglet’s birth weight and increase the
number of stillborn piglets and non-viable and immature born piglets. It is essential that
the mean length of gestation is calculated on each farm from past records and not to
anticipate the term of gestation by more than two days.
Injection into adipose tissue can result in incomplete absorption of the veterinary
medicinal product.
Cloprostenol may cause effects related to Prostaglandin activity in the smooth
muscles, such as increased frequency of urination and defecation.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Prostaglandins of the F2α type, such as cloprostenol, may be absorbed through the skin
and may cause bronchospasm or miscarriage. Care should be taken when handling the
veterinary medicinal product to avoid self-injection or skin contact.
Pregnant women, women of childbearing age, asthmatics and persons with other
respiratory tract diseases should avoid contact when handling this veterinary medicinal
product. Personal protective equipment consisting of impervious gloves should be worn
when handling the veterinary medicinal product.
Accidental spillage on the skin should be washed immediately with soap and water. In
case of accidental self-injection or spillage onto the skin seek medical advice
immediately, particularly as shortness of breath may occur, and show the package
leaflet or label to the physician.
This veterinary medicinal product may cause hypersensitive reactions. People with
known hypersensitivity to benzyl alcohol should avoid contact with the veterinary
medicinal product.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

The concomitant use of oxytocin and cloprostenol increases the effects on the uterus.
The concomitant use of progestogens decreases the effect of cloprostenol.
Do not administer with non-steroidal anti-inflammatory drugs (NSAIDs) since they inhibit
endogenous prostaglandin synthesis.

Keep the vial in the outer carton in order to protect from light.
Do not freeze.

Cattle:
Meat and offal: 1 day
Milk: Zero hours
Goats, horses, donkeys:
Meat and offal: 2 days
Milk: 24 hours
Pigs:
Meat and offal: 1 day

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.