Epromec 5 mg/ml Pour-on Solution for Beef and Dairy Cattle

Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
-
extended period of time.
-
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported
within the EU. However resistance to other macrocyclic lactones has been reported
in parasite species in cattle within the EU. Therefore, use of this product should be
based on local (regional, farm) epidemiological information about susceptibility of

Revised: August 2020
AN: 01389/2019
nematodes and recommendations on how to limit further selection for resistance to
anthelmintics.
If there is a risk for re- infection, the advice of a veterinarian should be sought
regarding the need for and frequency of repeat administration.
For the best results the product should be part of a programme to control both
internal and external parasites of cattle based on the epidemiology of these
parasites.

Special precautions for use in animals
For external use only.
For effective use, the product should not be applied to areas of the backline covered
with mud or manure.
The product should be applied only on healthy skin.
Not to be used in other species; avermectins can cause fatalities in dogs, especially
Collies, Old English Sheepdogs and related breeds and crosses, and also in
turtles/tortoises.
To avoid adverse reactions due to the death of warble larvae in the oesophagus or
backbone, it is recommended to administer the product after the end of warble fly
activity and before the larvae reach their resting sites in the body; consult a veterinary
surgeon regarding the appropriate time for treatment.
Rainfall at any time before or after treatment will not affect the efficacy of the product.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product may be irritating to human skin and eyes and may cause
hypersensitivity.
Avoid direct contact with the skin or eyes.
Wear rubber gloves and protective clothing when applying the product.
If accidental skin contact occurs, wash the affected area immediately with soap and
water. If accidental eye exposure occurs, flush eyes immediately with water.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Wash hands after use. Should clothing become contaminated, remove as soon as
possible and launder before re-use. In the event of ingestion, wash out mouth with
water and seek medical advice.
People with known hypersensitivity to the active substance or to any of the excipients
should avoid contact with the veterinary medicinal product.
Other precautions:
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils
and may accumulate in sediments. The risk to aquatic ecosystems and dung fauna
can be reduced by avoiding too frequent and repeated use of eprinomectin (and
products of the same anthelmintic class) in cattle. The risk to aquatic ecosystems will
be further reduced by keeping treated cattle away from water bodies for three weeks
after treatment.