POM-VPS
Prescription Required
Eprinex Pour-on for Beef and Dairy Cattle
Active ingredient: Eprinomectin
Form
Spot-on
Species
Cattle
Manufacturer
Boehringer Ingelheim Vetmedica GmbH
VMD MA No.
61700/5012
What it's used for
Ostertagia lyrata (adult), Ostertagia ostertagi ), Cooperia spp. (including inhibited Cooperia spp), Cooperia oncophora, AN: 01447/2024 & 01448/2024 Cooper...
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Paying less for Eprinomectin
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Prescription required
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Clinical information
Eprinex Pour-on for Beef and Dairy Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Ostertagia lyrata (adult),
Ostertagia ostertagi ),
Cooperia spp. (including inhibited Cooperia spp),
Cooperia oncophora,
AN: 01447/2024 & 01448/2024
Cooperia pectinata,
Cooperia punctata,
Cooperia surnabada,
Haemonchus placei,
Trichostrongylus spp.,
Trichostrongylus axei,
Trichostrongylus colubriformis,
Bunostomum phlebotomum,
Nematodirus helvetianus,
Oesophagostomum spp. (adult),
Oesophagostomum radiatum,
Trichuris spp (adult).
Lungworms (adults and fourth stage larvae):
Dictyocaulus viviparus
Warbles (parasitic stages):
Hypoderma bovis, H. lineatum
Mange Mites:
Chorioptes bovis, Sarcoptes scabiei var bovis
Lice:
Damalinia (Bovicola) bovis (biting lice), Linognathus vituli (sucking lice),
Haematopinus eurysternus (sucking lice), Solenopotes capillatus (sucking lice).
Horn Flies:
Haematobia irritans.
Prolonged Activity
Applied as recommended, the product prevents reinfections with:
Parasite * Prolonged Activity
Dictyocaulus viviparus up to 28 days
Ostertagia spp up to 28 days
Oesophagostomum radiatum up to 28 days
Cooperia spp up to 21 days
Trichostrongylus spp up to 21 days
Haemonchus placei up to 14 days
Nematodirus helvetianus
*The following parasite species are included within each of the relevant
AN: 01447/2024 & 01448/2024
genera: Ostertagia ostertagi, O. lyrata, Cooperia oncophora, C. punctata, C.
surnabada, Trichostronglus axei, T. colubroformis.
Ostertagia ostertagi ),
Cooperia spp. (including inhibited Cooperia spp),
Cooperia oncophora,
AN: 01447/2024 & 01448/2024
Cooperia pectinata,
Cooperia punctata,
Cooperia surnabada,
Haemonchus placei,
Trichostrongylus spp.,
Trichostrongylus axei,
Trichostrongylus colubriformis,
Bunostomum phlebotomum,
Nematodirus helvetianus,
Oesophagostomum spp. (adult),
Oesophagostomum radiatum,
Trichuris spp (adult).
Lungworms (adults and fourth stage larvae):
Dictyocaulus viviparus
Warbles (parasitic stages):
Hypoderma bovis, H. lineatum
Mange Mites:
Chorioptes bovis, Sarcoptes scabiei var bovis
Lice:
Damalinia (Bovicola) bovis (biting lice), Linognathus vituli (sucking lice),
Haematopinus eurysternus (sucking lice), Solenopotes capillatus (sucking lice).
Horn Flies:
Haematobia irritans.
Prolonged Activity
Applied as recommended, the product prevents reinfections with:
Parasite * Prolonged Activity
Dictyocaulus viviparus up to 28 days
Ostertagia spp up to 28 days
Oesophagostomum radiatum up to 28 days
Cooperia spp up to 21 days
Trichostrongylus spp up to 21 days
Haemonchus placei up to 14 days
Nematodirus helvetianus
*The following parasite species are included within each of the relevant
AN: 01447/2024 & 01448/2024
genera: Ostertagia ostertagi, O. lyrata, Cooperia oncophora, C. punctata, C.
surnabada, Trichostronglus axei, T. colubroformis.
For single application only.
To ensure a correct dosage, bodyweight should be determined as accurately as
possible. The use of suitably calibrated measuring equipment is recommended.
If animals are to be treated collectively rather than individually, reasonable
homogeneous groups should be set up, and all animals of a group should be dosed
at the rate corresponding to the heaviest one. Underdosing could result in ineffective
use and may favour resistance development.
Dosage:
Administer only by topical application at the dose rate of 1 ml per 10 kg of body
weight, corresponding to the recommended dose rate of 0.5 mg eprinomectin per kg
bodyweight.
Method of administration:
The veterinary medicinal product should be applied topically by pouring along the
backline in a narrow strip extending from the withers to the tailhead.
For 250 ml and 1 litre bottles:
Attach the dose dispenser to the bottle. Set the dose by turning the top section of the
dose dispenser to align the correct bodyweight with the pointer inside the
dose dispenser. When bodyweight is between markings, use the higher setting.
Hold the bottle upright and squeeze it to deliver a slight excess of the required dose
as indicated by the calibration lines.
By releasing the pressure, the dose automatically adjusts to the correct level. Tilt the
bottle to deliver the dose. For the 1 litre bottle: when a 10 ml or 15 ml dose is
required, turn the pointer to ‘’STOP’’ before delivering the dose. The off (STOP)
position will close the system between dosing.
The dose dispenser should not be stored attached to the bottle when not in use.
Remove the dose dispenser after each use and replace with the bottle cap.
For 2.5 and 5 litre backpacks:
Connect the dosing gun and draw-off tubing to the backpack as follows:
Attach the open end of the draw-off tubing to an appropriate dosing gun.
Attach draw-off tubing to the cap with the stem that is included in the pack. Replace
shipping cap with the cap having the draw-off tubing. Tighten the draw-off cap.
Gently prime the dosing gun, checking for leaks.
Follow the dosing gun manufacturer’s directions for adjusting the dose and proper
use and maintenance of the dosing gun and draw-off tubing.
To ensure a correct dosage, bodyweight should be determined as accurately as
possible. The use of suitably calibrated measuring equipment is recommended.
If animals are to be treated collectively rather than individually, reasonable
homogeneous groups should be set up, and all animals of a group should be dosed
at the rate corresponding to the heaviest one. Underdosing could result in ineffective
use and may favour resistance development.
Dosage:
Administer only by topical application at the dose rate of 1 ml per 10 kg of body
weight, corresponding to the recommended dose rate of 0.5 mg eprinomectin per kg
bodyweight.
Method of administration:
The veterinary medicinal product should be applied topically by pouring along the
backline in a narrow strip extending from the withers to the tailhead.
For 250 ml and 1 litre bottles:
Attach the dose dispenser to the bottle. Set the dose by turning the top section of the
dose dispenser to align the correct bodyweight with the pointer inside the
dose dispenser. When bodyweight is between markings, use the higher setting.
Hold the bottle upright and squeeze it to deliver a slight excess of the required dose
as indicated by the calibration lines.
By releasing the pressure, the dose automatically adjusts to the correct level. Tilt the
bottle to deliver the dose. For the 1 litre bottle: when a 10 ml or 15 ml dose is
required, turn the pointer to ‘’STOP’’ before delivering the dose. The off (STOP)
position will close the system between dosing.
The dose dispenser should not be stored attached to the bottle when not in use.
Remove the dose dispenser after each use and replace with the bottle cap.
For 2.5 and 5 litre backpacks:
Connect the dosing gun and draw-off tubing to the backpack as follows:
Attach the open end of the draw-off tubing to an appropriate dosing gun.
Attach draw-off tubing to the cap with the stem that is included in the pack. Replace
shipping cap with the cap having the draw-off tubing. Tighten the draw-off cap.
Gently prime the dosing gun, checking for leaks.
Follow the dosing gun manufacturer’s directions for adjusting the dose and proper
use and maintenance of the dosing gun and draw-off tubing.
This product is formulated only for topical application to beef and dairy cattle,
including lactating dairy cattle. Do not use in other animal species. Do not administer
orally or by injection.
Do not use in cases of hypersensitivity to the active substance(s) or to any of the
excipient(s).
including lactating dairy cattle. Do not use in other animal species. Do not administer
orally or by injection.
Do not use in cases of hypersensitivity to the active substance(s) or to any of the
excipient(s).
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Pruritus, alopecia
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
(<1 animal / 10,000 animals treated,
including isolated reports):
Pruritus, alopecia
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
For effective use, the veterinary medicinal product should not be applied to areas of
the backline covered with mud or manure.
Unnecessary use of antiparasitic or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode
of action should be used. Confirmed resistance should be reported to the marketing
authorisation holder or to the competent authorities.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported
within the EU. However, resistance to other macrocyclic lactones has been reported
in nematode populations in cattle within the EU, which may be associated with side-
resistance to eprinomectin. The use of this veterinary medicinal product should take
into account local information about susceptibility of target parasites, where available.
While mite and louse numbers decline rapidly following treatment, due to the feeding
habits of some mites, in some cases several weeks may be required for complete
eradication.
Special precautions for safe use in the target species:
For external use only.
The veterinary medicinal product should be applied only on healthy skin.
To avoid secondary reactions due to the death of
oesophagus or in the spine, it is recommended to administer the veterinary medicinal
product at the end of warble fly activity and before the larvae reach their resting sites.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
•
should avoid contact with the veterinary medicinal product.
•
cause hypersensitivity.
•
treatment and when handling recently treated animals.
•
waterproof coat should be worn when handling the veterinary medicinal product.
•
before re-use.
•
soap and water and water, and seek medical advice immediately and show the
package leaflet or the label to the physician.
•
medical advice show the package leaflet or the label to the physician .
•
of the product by hand to mouth contact.
•
•
medical advice immediately and show the package leaflet or the label to the
physician.
•
Other precautions for the protection of the environment:
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils
and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding repeated
use of eprinomectin (and products of the same anthelmintic class).
In order to reduce the risk to aquatic ecosystems, treated animals should not have
direct access to water bodies for two to five weeks after treatment.
the backline covered with mud or manure.
Unnecessary use of antiparasitic or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode
of action should be used. Confirmed resistance should be reported to the marketing
authorisation holder or to the competent authorities.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported
within the EU. However, resistance to other macrocyclic lactones has been reported
in nematode populations in cattle within the EU, which may be associated with side-
resistance to eprinomectin. The use of this veterinary medicinal product should take
into account local information about susceptibility of target parasites, where available.
While mite and louse numbers decline rapidly following treatment, due to the feeding
habits of some mites, in some cases several weeks may be required for complete
eradication.
Special precautions for safe use in the target species:
For external use only.
The veterinary medicinal product should be applied only on healthy skin.
To avoid secondary reactions due to the death of
oesophagus or in the spine, it is recommended to administer the veterinary medicinal
product at the end of warble fly activity and before the larvae reach their resting sites.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
•
should avoid contact with the veterinary medicinal product.
•
cause hypersensitivity.
•
treatment and when handling recently treated animals.
•
waterproof coat should be worn when handling the veterinary medicinal product.
•
before re-use.
•
soap and water and water, and seek medical advice immediately and show the
package leaflet or the label to the physician.
•
medical advice show the package leaflet or the label to the physician .
•
of the product by hand to mouth contact.
•
•
medical advice immediately and show the package leaflet or the label to the
physician.
•
Other precautions for the protection of the environment:
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils
and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding repeated
use of eprinomectin (and products of the same anthelmintic class).
In order to reduce the risk to aquatic ecosystems, treated animals should not have
direct access to water bodies for two to five weeks after treatment.
No interactions with other medicines and no other forms of interactions are known.
Since eprinomectin binds extensively to plasma proteins, this should be taken into
account if it is used in association with other molecules having the same
characteristics.
Since eprinomectin binds extensively to plasma proteins, this should be taken into
account if it is used in association with other molecules having the same
characteristics.
Keep the bottle or backpack in the outer carton in order to protect from light. This
veterinary medicinal product does not require any special temperature storage
conditions.
veterinary medicinal product does not require any special temperature storage
conditions.
Qualitative composition of
excipients and other constituents
Quantitative composition if that
information is essential for
proper administration of the
veterinary medicinal product
Butylhydroxytoluene (E321)0.1 mgPropylene glycol octanoate
decanoate
Clear, slightly yellow pour-on solution
3.CLINICAL INFORMATION3.1Target speciesCattle (beef and dairy cattle).3.2Indications for use for each target speciesIndicated for treatment and control of the following parasites:ParasiteAdultL4Inhibited L4Gastrointestinal roundworms:
Ostertagia spp.
Ostertagia lyrataOstertagia ostertagiCooperia spp.Cooperia oncophoraCooperia pectinataCooperia punctataCooperia surnabadaHaemonchus placeiTrichostrongylus spp.Trichostrongylus axeiTrichostrongylus colubriformisBunostomum phlebotomumNematodirus helvetianusOesophagostomum spp.
Oesophagostomum radiatumTrichuris spp.
Lungworms
Dictyocaulus viviparus
Warbles (parasitic stages)
Hypoderma bovisH. lineatum
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Lice
Damalinia bovis (biting lice)Linognathus vituli Haematopinus eurysternus
(sucking lice)
Solenopotes capillatus
lice)
Prolonged Activity: applied as recommended, the veterinary medicinal
product controls reinfections with:
Parasite* Prolonged Activity
Dictyocaulus viviparus
Ostertagia spp. up to 28 days
Oesophagostomum radiatum
Cooperia spp. up to 21 days
Trichostrongylus spp up to 21 days
Haemonchus placei
Nematodirus helvetianus
* The following parasite species are included within each of the relevant
genera:
Ostertagia ostertagi, O. lyrata, Cooperia oncophora, C. punctata, C.
surnabada, Trichostrongylus axei, T. colubriformis.
For best results the veterinary medicinal product should be part of a
programme to control both internal and external parasites of cattle based on
the epidemiology of these parasites.
3.3Contraindications
This veterinary medicinal product is formulated only for topical application to beef and
dairy cattle, including lactating dairy cattle.
Do not use in other animal species. Avermectins can cause fatalities in dogs,
especially Collies, Old English Sheepdogs and related breeds and crosses, and also
in turtles/tortoises.
Do not administer orally or by injection.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
3.4 Special warnings
For effective use, the veterinary medicinal product should not be applied to areas of
the backline covered with mud or manure.
Unnecessary use of antiparasitic or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another
excipients and other constituents
Quantitative composition if that
information is essential for
proper administration of the
veterinary medicinal product
Butylhydroxytoluene (E321)0.1 mgPropylene glycol octanoate
decanoate
Clear, slightly yellow pour-on solution
3.CLINICAL INFORMATION3.1Target speciesCattle (beef and dairy cattle).3.2Indications for use for each target speciesIndicated for treatment and control of the following parasites:ParasiteAdultL4Inhibited L4Gastrointestinal roundworms:
Ostertagia spp.
Ostertagia lyrataOstertagia ostertagiCooperia spp.Cooperia oncophoraCooperia pectinataCooperia punctataCooperia surnabadaHaemonchus placeiTrichostrongylus spp.Trichostrongylus axeiTrichostrongylus colubriformisBunostomum phlebotomumNematodirus helvetianusOesophagostomum spp.
Oesophagostomum radiatumTrichuris spp.
Lungworms
Dictyocaulus viviparus
Warbles (parasitic stages)
Hypoderma bovisH. lineatum
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Lice
Damalinia bovis (biting lice)Linognathus vituli Haematopinus eurysternus
(sucking lice)
Solenopotes capillatus
lice)
Prolonged Activity: applied as recommended, the veterinary medicinal
product controls reinfections with:
Parasite* Prolonged Activity
Dictyocaulus viviparus
Ostertagia spp. up to 28 days
Oesophagostomum radiatum
Cooperia spp. up to 21 days
Trichostrongylus spp up to 21 days
Haemonchus placei
Nematodirus helvetianus
* The following parasite species are included within each of the relevant
genera:
Ostertagia ostertagi, O. lyrata, Cooperia oncophora, C. punctata, C.
surnabada, Trichostrongylus axei, T. colubriformis.
For best results the veterinary medicinal product should be part of a
programme to control both internal and external parasites of cattle based on
the epidemiology of these parasites.
3.3Contraindications
This veterinary medicinal product is formulated only for topical application to beef and
dairy cattle, including lactating dairy cattle.
Do not use in other animal species. Avermectins can cause fatalities in dogs,
especially Collies, Old English Sheepdogs and related breeds and crosses, and also
in turtles/tortoises.
Do not administer orally or by injection.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
3.4 Special warnings
For effective use, the veterinary medicinal product should not be applied to areas of
the backline covered with mud or manure.
Unnecessary use of antiparasitic or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where
the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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