Epricert 5 mg/ml Pour-on Solution for Beef and Dairy Cattle, Sheep and Goats

For effective use, the veterinary medicinal product should not be applied to areas
of the backline covered with mud or manure.
In cattle, rainfall before, during or after the application of the veterinary medicinal
product, has been shown to have no impact on its efficacy. It also has been
demonstrated that haircoat length has no impact on the veterinary medicinal
product’s efficacy. The effect of rainfall and haircoat length on efficacy has not
been evaluated in sheep and goats.
In order to limit cross-transfer of eprinomectin, treated animals should preferably
be separated from untreated animals. Non-compliance with this recommendation
may lead to residue violations in untreated animals and development of
resistance to eprinomectin.
Unnecessary use of antiparasitics or use deviating from the instructions given in
the SPC may increase the resistance selection pressure and lead to reduced
efficacy. The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based
on its epidemiological features, for each herd/flock.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd/flock,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd/flock should be
avoided. Instead, if feasible, only selected individual animals or subgroups should
be treated (targeted selective treatment). This should be combined with
appropriate husbandry and pasture management measures. Guidance for each
specific herd/flock should be sought from the responsible veterinarian.
It is recommended to further investigate cases of suspected resistance, using
appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used. Confirmed resistance should be reported to the marketing
authorisation holder or to the competent authorities.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported
in cattle while resistance to eprinomectin has been reported in goats and sheep
within the EU.
However, resistance to other macrocyclic lactones has been reported in
nematode populations in cattle, sheep and goats within the EU, which may be
associated with side-resistance to eprinomectin. The use of this veterinary
medicinal product should take into account local information about susceptibility
of the target parasites, where available.
While mite and louse numbers decline rapidly following treatment, due to the
feeding habits of some mites, in some cases several weeks may be required for
complete eradication.

Special precautions for safe use in the target species:
For external use only.
The veterinary medicinal product should be applied only on healthy skin.
To avoid secondary reactions due to the death of
oesophagus or in the spine, it is recommended to administer the veterinary
medicinal product at the end of warble fly activity and before the larvae reach
their resting sites.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
People with known hypersensitivity to the active substance or to any of the
excipients should avoid contact with the veterinary medicinal product.
This veterinary medicinal product may be irritating to skin and eyes. Avoid
contact with eyes and skin.
Personal protective equipment consisting of rubber gloves, boots and waterproof
coat should be worn when handling the veterinary medicinal product.
Should clothing become contaminated, remove as soon as possible and launder
before re-use. If accidental skin contact occurs, wash the affected area
immediately with soap and water. If accidental eye exposure occurs, flush eyes
immediately with plenty of clean water. Should irritation persist, seek medical
advice and show the package leaflet or the label to the physician. Do not ingest.
In case of accidental ingestion, rinse out mouth thoroughly with water, seek medical
advice immediately and show the package leaflet or the label to the physician.
Do not smoke, eat or drink while handling the veterinary medicinal product. Wash
hands after use.
Special precautions for the protection of the environment:
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils
and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding repeated
use of eprinomectin (and products of the same anthelmintic class).
In order to reduce the risk to aquatic ecosystems, treated animals should not have
direct access to water bodies for two to five weeks after treatment.