POM-V Prescription Required

Dalmazin, 75 Micrograms/ml, Solution for Injection for Cattle, Buffaloes and Pigs

Active ingredient: Cloprostenol

Form

Injection

Species

Buffalo Cattle Pigs

Manufacturer

Fatro S.p.A

VMD MA No.

11557/5003

What it's used for

Cattle (cows) and buffaloes (female) Indications for reproduction: synchronisation or induction of oestrus. Induction and synchronisation of oestrus and ov...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Cloprostenol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Dalmazin, 75 Micrograms/ml, Solution for Injection for Cattle, Buffaloes and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Cattle (cows) and buffaloes (female)
Indications for reproduction: synchronisation or induction of oestrus. Induction and
synchronisation of oestrus and ovulation in combination
with GnRH or GnRH analogue, with or without
progesterone, as part of fixed time artificial insemination
(FTAI) protocols. Induction of parturition after day 270 of
gestation in cattle and within 10-15 days before expected
calving in buffaloes
Therapeutic indications: ovarian dysfunction (persistent corpus luteum, luteal cyst),
treatment of uterine disorders related to a functioning or
persistent corpus luteum (endometritis/pyometra).

Revised: August 2025
AN: 03113/2024
Cattle (cows)
Zootechnical indications: induction of abortion in the first half of pregnancy.
Therapeutic indications: delayed uterine involution and expulsion of mummified
foetuses.
Pigs (sows and young females)
Indications for reproduction: induction of parturition.

Do not use in pregnant females, unless it is desirable to induce parturition or induction of
abortion.
Do not use in animals which are expected to have dystocia due to abnormal
position/presentation of the foetus, mechanical obstruction, etc.
Do not use in animals suffering cardiovascular or respiratory diseases.
Do not use in animals with spastic diseases of the respiratory or gastrointestinal tract.
Do not administer by intravenous route.

Cattle (cows), buffaloes (female) and pigs (sows and young females):
Undetermined frequencyInjection site infection
a
.
Injection site swelling
a
.
Crepitus
a
.
Retained placenta
b
.
Behavioural changes
c
.
a
due to anaerobic infection, especially after intramuscular injection in cows.
b
dependent on the time of treatment relative to the date of conception, the incidence in
cows may be increased.
c
similar to those changes associated with natural farrowing in sows usually ceasing within
one hour.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also the section of the package
leaflet for respective contact details.

The response of animals to the synchronisation protocols is not homogeneous between
herds, nor within the same herd, and may vary depending on the physiological state of the
animal at the time of treatment (sensitivity and a functional state of the corpus luteum, age,
physical condition, interval from calving, etc.).
The efficacy of cloprostenol treatment in buffaloes may show a wide variation throughout
the year as climate and particularly the photoperiod plays a pivotal role in the reproductive
seasonality.

Special precautions for use in animals
As with parenteral administration of any substance, basic antiseptic rules should be
observed.
The injection site must be thoroughly cleaned and disinfected in order to reduce the risk of
infection with anaerobic bacteria.
Induction of labour before the 111th day of gestation may cause mortality in piglets and an
increase in the number of sows that require manual assistance.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Prostaglandins of the F2α type can be absorbed through the skin and
bronchospasm or miscarriage.
Chlorocresol may cause irritation and allergic reactions. People with known
hypersensitivity to chlorocresol should administer the veterinary medicinal product with
caution.
Care should be taken when handling the product to avoid self-injection or skin contact.
Pregnant women, women of child-bearing age, asthmatics and people with bronchial or
other respiratory problems, should avoid contact with, or wear disposable plastic gloves
when administering the product.

Revised: August 2025
AN: 03113/2024
Accidental spillage on the skin should be washed off immediately with soap and water.
In case of accidental self-injection seek medical advice immediately and show the package
leaflet or the label to the physician.
Should shortness of breath result from accidental inhalation or injection, seek urgent
medical advice and show the doctor this warning.
Do not eat, drink or smoke while handling the product
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.

Do not administer the treatment together with non-steroidal anti-inflammatory drugs since
they inhibit endogenous prostaglandin synthesis.
The activity of other oxytocic agents can be increased after the administration of
cloprostenol.

Revised: August 2025
AN: 03113/2024

Store below 25°C.

Cattle (cows): Meat and offal: Zero days
Milk: Zero hours
Buffaloes (female): Meat and offal: 1 day
Milk: Zero hours
Pigs (sows and young females): Meat and offal: 1 day
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.