Dalmazin, 75 Micrograms/ml, Solution for Injection for Cattle, Buffaloes and Pigs

Cattle (cows) and buffaloes (female)
Administer 2 ml of the veterinary medicinal product, equivalent to 150 micrograms of
(+)-
Cloprostenol/animal by intramuscular route.
In particular:
•
established the presence of a corpus luteum (6-18
th
day of the cycle); heat
usually appears within 48-60 hours. Proceed, therefore, with insemination 72-96
hours after injection. If oestrus is not evident, administration of the product needs
to be repeated 11 days after the first injection.
•
with an interval of 11 days between each dose. Proceed therefore with two
artificial inseminations at intervals of 72 and 96 hours from the second injection.
•
or GnRH analogue, with or without progesterone, as part of fixed time artificial
insemination (FTAI) protocols (e.g. OvSynch).
Judgment on the protocol to be used should be made by responsible veterinarian,
on the basis of the intended objective and characteristics of the individual herd or
animal.
The following protocols have been evaluated and could be used:
The OvSynch (i.e. GnRH/prostaglandin/GnRH) protocol for breeding dairy cows
and female buffaloes at a pre-planned time without the need for specific heat
detection is summarised below:
Day 0 GnRH or GnRH analogue
Day 7 2 ml of the product (150 micrograms of (+)-Cloprostenol)
Day 9 GnRH or GnRH analogue
AI 16 - 20 hours after the second GnRH or GnRH analogue injection, or
at observed oestrus if sooner
The OvSynch protocol combined with progesterone supplementation for breeding
dairy cows and female buffaloes at a pre-planned time without the need for
specific heat detection is summarised below:
Day 0 Insert progesterone releasing intravaginal device
Administer GnRH or GnRH analogue
Day 7 Remove device
Administer 2 ml of the product (150 micrograms of (+)-Cloprostenol)
Day 9 GnRH or GnRH analogue
AI 16 - 20 hours after the second GnRH or GnRH analogue injection, or
at observed oestrus if sooner
Other protocols may be equally relevant.
•
of pregnancy in cattle and within 10-15 days before expected calving in buffaloes.
Birth usually results within 30-60 hours of treatment.
•
veterinary medicinal product, then proceed to inseminate at the first oestrus after
injection. If oestrus is not evident, conduct a further gynaecological examination,
and repeat the injection 11 days after the first administration. Insemination must
always be carried out 72-96 hours after injection.
•
necessary repeat the treatment after 10-11 days.
Cattle (cows)
•
administration of the veterinary medicinal product.
•
half of pregnancy.
•
considered necessary, carry out one or two successive treatments at 24 hour
intervals.
Pigs (sows and young females)
Administer 1 ml of the veterinary medicinal product, equivalent to 75 micrograms of
(+)- Cloprostenol/animal, by intramuscular route, not earlier than 112 days of
pregnancy. Repeat after 6 hours. Alternatively, 20 hours after the initial dose of the
veterinary medicinal product, a myometrial stimulant (oxytocin or carazolol) may be
administered.
Following the protocol of the double administration, approximately 70-80% of the
animals will give birth during the interval between 20 and 30 hours after the first
administration.
As with every prostaglandin-based product, injection in contaminated skin areas is to
be avoided in order to reduce the risk of infection with anaerobic bacteria.
The injection site must be thoroughly cleaned and disinfected before
administration.
The closures should not be punctured more than 25 times for all the
pack sizes from 10 ml to 100 ml and more than 2 times for the 2 ml
pack size.