POM-V Prescription Required

Cyclix 87.5 µg/ml Solution for Injection for Pigs

Active ingredient: Cloprostenol

Form

Injection

Species

Pigs

Manufacturer

Virbac

VMD MA No.

05653/3010

What it's used for

- - -

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Cloprostenol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Cyclix 87.5 µg/ml Solution for Injection for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

-
-
-

To be administered by deep intramuscular route with a needle at least 4 cm long.
Administer a single dose of 2 ml per animal (equivalent to 175 micrograms of
cloprostenol).
The stopper may be safely punctured up to 10 times. When treating groups of animals in
one run, use a draw-off needle that has been placed in the vial stopper to avoid excess
broaching of the stopper. The draw-off needle should be removed after treatment.

Do not use in pregnant animals in which the induction of parturition is not intended.
Do not administer to induce parturition in animals with suspected dystocia due to
mechanical obstruction or abnormal position, presentation and/or posture of the foetus.
Do not use in cases of bronchospasm or gastrointestinal dysmotility.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

Pigs (sows):
Rare
(1 to 10 animals / 10,000 animals
treated)
Injection site infection
; Very rare
(<1 animal / 10,000 animals
treated, including isolated reports):
Restlessness
,
Frequent urination
;
Diarrhoea
Retained placenta
, Metritis
, Dystocia
,
Stillbirth
1
May occur if anaerobic bacteria enter the injection site and may become generalized.
Careful aseptic techniques should be employed to decrease the possibility of these
infections.
May be observed within 15 minutes post-injection and usually disappears after one hour.
May be caused by induction of parturition with any exogenous compound.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

The response of sows to induction of parturition may be influenced by the physiological
state and the time of treatment. The vast majority of the animals, 95%, will commence
farrowing within 36 hours of treatment. The majority of animals can be expected to
respond within the period of 24+/- 5 hours following the injection, except in those cases
where spontaneous parturition is imminent.

Special precautions for safe use in the target species:
To reduce the risk of anaerobic infections arising from vasoconstriction at the injection site,
injections into contaminated (wet or dirty) skin areas should be avoided. Thoroughly clean
and disinfect injection sites prior to administration.
Injection into adipose tissue may lead to incomplete absorption of the veterinary medicinal
product.
Premature induction of farrowing will reduce the piglet`s birth weight and increase the
number of stillborn piglets and non-viable and immature born piglets. It is essential that the
mean length of gestation is calculated on each farm from past records and not to
anticipate the term of gestation by more than two days.
Do not administer intravenously.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Prostaglandins of the type, such as cloprostenol, may be absorbed through the skin
and may cause bronchospasm or miscarriage.
Care should be taken when handling the veterinary medicinal product to avoid self-
injection or skin contact.
Pregnant women, women of childbearing age, asthmatics and persons with other
respiratory tract diseases should avoid contact when handling this veterinary medicinal
product.
Personal protective equipment consisting of impervious gloves should be worn when
handling the veterinary medicinal product.
Accidental spillage on the skin should be washed immediately with soap and water. In
case of accidental self-injection or spillage onto the skin seek medical advice immediately,
particularly as shortness of breath may occur, and show the package label or leaflet to the
physician.
This veterinary medicinal product may cause hypersensitivity reactions. People with known
hypersensitivity to benzyl alcohol should avoid contact with the veterinary medicinal
product.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

The concomitant use of oxytocin and cloprostenol increases the effects on the uterus.
Do not administer with non-steroidal anti-inflammatory drugs (NSAIDs) since they inhibit
endogenous prostaglandin synthesis.
In animals to which a progestogen is being administered, a decrease in the response of
cloprostenol can be expected.

Keep the vial in the outer carton
Protect from light.

Meat and offal: 1 day.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.