CaniTrio Chewable Tablets for Dogs >10-20 kg

Ticks and fleas need to start feeding on the host to become exposed to sarolaner;
therefore, the transmission of infectious parasite-borne diseases cannot be
excluded.
This veterinary medicinal product is not effective against adult D. immitis. However,
accidental administration to dogs infected with adult heartworms should not pose
safety concerns. Dogs in areas endemic for heartworm (or those which have
travelled to endemic areas) may be infected with adult heartworms. Maintenance of
the efficacy of macrocyclic lactones is critical for Dirofilaria immitis control. To
minimise the risk of resistance selection, it is recommended that dogs should be
checked for both circulating antigens and blood microfilariae at the beginning of each
season of preventative treatment. Only negative animals should be treated.

Revised: November 2025
AN: 01691/2025
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of based on its epidemiological features, for each
animal.
Parasite resistance to any particular class of parasiticides may develop following the
frequent, repeated use of a product of that class. Therefore, the use of this product
should be based on the assessment of each individual case and on local
epidemiological information about the current susceptibility of the target species in
order to limit the possibility of a future selection for resistance.
The possibility that other animals in the same household can be a source of re-
infection should be considered, and these should be treated as necessary with an
appropriate product.

Special precautions for use in animals
In the absence of available data, treatment of puppies less than 8 weeks of age
and/or dogs less than 1.25 kg bodyweight should be based on a benefit-risk
assessment by the responsible veterinarian.
The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1
(MDR1 -/-). However, in such sensitive breeds (which may include, but not
necessarily limited to, Collies and related breeds), the recommended dose should be
strictly observed.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after handling the product.
The accidental ingestion of the product may potentially result in adverse effects,
such as transient excitatory neurological signs. To prevent children from accessing
the product, only one chewable tablet at a time should be removed from the blister
pack and only when required. The blister pack should then be returned into the
carton immediately after use and the carton should be stored out of the sight and
reach of children. In case of accidental ingestion, seek medical advice immediately
and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

Revised: November 2025
AN: 01691/2025