Canigen Lepto 2 Suspension for Injection for Dogs

A transient rise in body temperature post-vaccination has been observed in rare cases
during the clinical safety studies.
Dogs may show local reactions after injection in very rare cases, according to
spontaneous pharmacovigilance reports. A diffuse swelling, up to 5 cm in diameter,
may be observed at the site of injection for up to 4 days. Occasionally this swelling may
be hard and painful, but this will diminish gradually and disappear after 2 – 3 weeks.
A transient acute hypersensitivity reaction - with signs that may include lethargy, facial
oedema, pruritus, vomiting or diarrhoea - may occur shortly after vaccination in very
rare cases. Such reactions may evolve to a more severe condition (anaphylaxis), which
may be life-threatening with additional signs like dyspnoea or collapse. If such reactions
occur appropriate treatment is recommended.
Mild systemic signs such as lethargy and anorexia were reported very rarely.
Clinical signs of immune-mediated haemolytic anaemia, immune-mediated
thrombocytopenia, or immune-mediated polyarthritis have been reported in very rare
cases.

Amended pages: October 2025
AN: 01413/2025
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).