Versican Plus DHPPi/L4 Lyophilisate and Suspension for Suspension for Injection for Dogs
Active ingredients: Canine adenovirus, Canine distemper virus, Canine parainfluenza virus, Canine parvovirus, Leptospira interrogans serogroup Australis, Leptospira interrogans serogroup Canicola, Leptospira interrogans serogroup Icterohaemorrhagiae, Leptospira kirschneri serogroup Grippotyphosa
Form
Injection
Species
Manufacturer
Zoetis UK Limited
VMD MA No.
42058/5083
What it's used for
Active immunisation of dogs from 6 weeks of age: - to prevent mortality and clinical signs caused by canine distemper virus, - to prevent mortality and cli...
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Prescription required
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Versican Plus DHPPi/L4 Lyophilisate and Suspension for Suspension for Injection for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
- to prevent mortality and clinical signs caused by canine distemper virus,
- to prevent mortality and clinical signs caused by canine adenovirus type 1,
- to prevent clinical signs and reduce viral excretion caused by canine
adenovirus type 2,
- to prevent clinical signs, leucopoenia and viral excretion caused by canine
parvovirus,
- to prevent clinical signs (nasal and ocular discharge) and reduce viral
excretion caused by canine parainfluenza virus,
- to prevent clinical signs, infection and urinary excretion caused by L.
interrogans serogroup Australis serovar Bratislava,
- to prevent clinical signs and urinary excretion and reduce infection caused by
L. interrogans serogroup Canicola serovar Canicola and L. interrogans
serogroup Icterohaemorrhagiae serovar Icterohaemorrhagiae and
- to prevent clinical signs and reduce infection and urinary excretion caused by
L. kirschneri serogroup Grippotyphosa serovar Grippotyphosa.
Onset of immunity:
- 3 weeks after the first vaccination for CDV, CAV, CPV,
- 3 weeks after completion of the primary course for CPiV and
- 4 weeks after completion of the primary course for Leptospira components.
Duration of immunity:
At least three years following the primary vaccination course for canine distemper
virus, canine adenovirus type 1, canine adenovirus type 2 and canine parvovirus.
The duration of immunity against CAV-2 was not established by challenge. It was
shown that 3 years after the vaccination CAV-2 antibodies are still present.
Protective immune response against CAV-2 associated respiratory disease is
considered to last at least 3 years. At least one year following the primary
vaccination course for canine parainfluenza virus and Leptospira components.
Common
(1 to 10 animals / 100 animals
treated):
injection site swelling
Rare
(1 to 10 animals / 10,000 animals
treated):
hypersensitivity reaction
(anaphylaxis,
angioedema, circulatory shock, collapse,
diarrhoea, dyspnoea, vomiting)
anorexia, decreased activity
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
hyperthermia, lethargy, malaise
immune mediated haemolytic anaemia,
immune mediated haemolytic
thrombocytopenia, immune mediated
polyarthritis
Issued: June 2024
AN: 03459/2022
A transient swelling (up to 5 cm) which can be painful, warm or reddened. Any such
swelling will either have spontaneously resolved or be greatly diminished by 14 days
after vaccination.
If a hypersensitivity reaction occurs, appropriate treatment should be administered
without delay. Such reactions may evolve to a more severe condition which may be
life-threatening.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for contact details.
Immunocompetence of the animal may be compromised by a variety of factors
including poor health, nutritional status, genetic factors, concurrent medicinal therapy
and stress.
Issued: June 2024
AN: 03459/2022
Immunological responses to the CDV, CAV and CPV components of the vaccine
may be delayed due to maternally derived antibody interference. However, the
vaccine has been proven to be protective against virulent challenge in the presence
of maternally derived antibodies to CDV, CAV and CPV at levels equal or higher to
those likely to be encountered under field conditions. In situations where very high
maternally derived antibody levels are expected, the vaccination protocol should be
planned accordingly.
Vaccinate healthy animals only.
Special precautions for use in animals
The live attenuated virus vaccine strains CAV-2, CPiV and CPV-2b may be shed by
vaccinated dogs following vaccination, shedding of CPV has been shown for up to
10 days. However, due to the low pathogenicity of these strains, it is not necessary
to keep vaccinated dogs separated from non-vaccinated dogs and domestic cats.
The vaccine virus strain CPV-2b has not been tested in other carnivores (except
dogs and domestic cats) that are known to be susceptible to canine parvoviruses
and therefore vaccinated dogs should be separated from them after vaccination.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.
Rabies:
If protection against Rabies is required:
First dose: Versican Plus DHPPi/L4 from 8–9 weeks of age.
Second dose: Versican Plus DHPPi/L4R 3–4 weeks later but not before 12 weeks of
age.
The efficacy of the rabies fraction is proven after a single dose from 12 weeks of age
in laboratory studies. However, in field studies 10% of sero-negative dogs did not
show seroconversion (>0.1 IU/ml) 3–4 weeks after single primary vaccination against
rabies. Some animals may also not show titres > 0.5 IU/ml after the primary
vaccination. Antibody titres drop over the course of the 3-year duration of immunity,
although dogs are protected when challenged. In case of travelling to risk areas or
outside the UK, veterinary surgeons may wish to give additional rabies vaccinations
after 12 weeks of age to ensure that the vaccinated dogs have an antibody titre of ≥
0.5 IU/ml, which is generally regarded as sufficiently protective and that they meet
the travel test requirements (antibody titres ≥ 0.5 IU/ml).
In case of need, dogs younger than 8 weeks can be vaccinated as safety of Versican
Plus DHPPi/L4R has been demonstrated in 6-week old dogs.
Do not freeze.
Protect from light.
Canine adenovirus Type 2, strain CAV-2 Bio 13 10
3.6
TCID50* 10
5.3
TCID50*
Canine parvovirus Type 2b, strain CPV-2b Bio 12/B 10
4.3
TCID50* 10
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Canine adenovirus
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Canigen DHP Lyophilisate and Solvent for Suspension for Injection for Dogs
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POM-VVirbac
Canixin DHPPi Lyophilisate and Solvent for Suspension for Injection for Dogs
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CANIXIN DHPPi/L Lyophilisate and Suspension for Suspension for Injection for Dogs
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