CANIXIN DHPPi/L Lyophilisate and Suspension for Suspension for Injection for Dogs

For active immunisation of dogs from 8 weeks of age to:
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parvovirus in challenge studies performed with a CPV-2b strain;
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challenge study performed with a CPV-2c strain;
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parainfluenza virus and canine adenovirus type 2;
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lesions and urine shedding of L.Canicola;
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Icterohaemorrhagiae;
Onset of immunity:
The onset of immunity has been demonstrated from 3 weeks after the primary
vaccination for CDV, CAV-2 and CPV, 4 weeks for CAV-1 and CPiV, 5 weeks for
Canicola and 2 weeks for Icterohaemorrhagiae.
Duration of immunity:
After the primary vaccination course, the duration of immunity lasts for one year for
all components.
In the duration of immunity studies one year after the basic vaccination scheme there
was no significant difference between vaccinated and control dogs in viral excretion
for CPiV and CAV-2, in reduction of kidney colonisation for
Icterohaemorrhagiae, nor in renal lesions and urine shedding for L. Canicola.
After the annual booster, the duration of immunity lasts for 3 years for CDV, CAV-1,
CAV-2 and CPV.
For CAV-2, the duration of immunity after the annual booster was not established by
challenge, and is based on the presence of CAV-2 antibodies 3 years after the
booster vaccination.