Apivar 500 mg Bee-hive Strips for Honey Bees
Active ingredient: Amitraz
Form
Bee-hive strip
Species
Manufacturer
Veto-Pharma SAS
VMD MA No.
51567/3000
What it's used for
Treatment of external parasitosis in honey bees caused by Varroa destructor .
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Apivar 500 mg Bee-hive Strips for Honey Bees — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
1.Separate the double strip.
2.Push the strip’s V-shaped die-cut outside.
3.Push each strip between the head of two frames
bee cluster with a minimum distance of 2 frames between strips. The strips
should be placed in such a way that the bees can have free access to both
sides.
Alternatively, the strips can be hung by the hole in the V-shaped die-cut, using a
small clove (or toothpick or hanger) fixed on the frame.
AN: 01357/2024 & 01394/2024Page 4 of 6
If brood is not present or at its lowest level, the strips can be removed after 6 weeks
of treatment. If brood is present, leave the strips in place for 10 weeks and remove
the strips at the end of treatment. In case the strips are covered by propolis and/or
wax, at mid-treatment, it is possible to gently scratch the strips using a hive tool.
Then, the strips should be placed in the hive again and repositioned, if necessary, in
order to match the application instructions above (in case of changes in the bee
cluster or brood area).
The recommended time for treatment is when honey supers are not present after the
last honey harvest (late summer/autumn) and before spring honey-producing activity
commences. Infestation monitoring is recommended to determine the best time for
treatment.
AN: 01357/2024 & 01394/2024Page 3 of 6
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Behavioural disorder
1
A transient change in behaviour (e.g. fleeing reaction, aggressive behaviour) may be
observed when the strips are first placed in the hive. This is believed to be a
defensive behaviour rather than an adverse reaction to the veterinary medicinal
product, per se.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system.
See the package leaflet for respective contact details.
but after the honey harvest. See section “Amount to be administered and
administration route”.
Do not cut the strips.
All colonies in the same apiary should be treated simultaneously to avoid
reinfestation.
Do not re-use the strips.
AN: 01357/2024 & 01394/2024Page 2 of 6
The safety and efficacy of the veterinary medicinal product has only been
investigated in hives with a single brood chamber (dose of 2 strips per hive/brood
chamber). Use in hives with more than one brood chamber is not recommended.
Inappropriate use of the veterinary medicinal product could result in an increased risk
of resistance development and could ultimately result in ineffective therapy.
Bee colonies should be monitored routinely for the level of varroa mite infestation,
specifically before the treatment and for a period thereafter.
The veterinary medicinal product should be used as part of an integrated varroa
control program and treatment rotation should be applied.
Amitraz resistance has been reported in some populations of Varroa mites.
In case of use in regions with suspected amitraz resistance, it is recommended that
the use of the veterinary medicinal product should be based on results of
susceptibility testing, and it is recommended to seek advice from your veterinarian or
local bee inspector.
Special precautions for safe use in the target species:
Do not exceed or reduce the recommended dose and recommended duration of use.
Remove the strips at the end of treatment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product contains amitraz which can lead to neurological
side-effects in humans. Amitraz is a monoamine oxidase inhibitor; therefore, take
particular care if you are taking monoamine oxidase inhibitors, hypotensive treatment
or if you have diabetes
Amitraz may cause skin sensitization (allergic reactions, particularly skin rashes).
Avoid contact with skin. In case of contact, wash thoroughly with soap and water.
Avoid contact with eyes. In case of contact, rinse with plenty of water immediately.
Personal protective equipment consisting of impervious gloves and the usual
beekeeping protective clothing should be worn when handling the veterinary
medicinal product.
If irritation occurs, seek medical advice immediately and show the package leaflet or
the label to the physician.
Do not eat, drink or smoke whilst handling the veterinary medicinal product.
Keep children away during application of the veterinary medicinal product.
Wash hands after use.
Do not inhale or ingest.
Special precautions for the protection of the environment:
Do not throw strips or empty sachets in ponds or streams, as the veterinary medicinal
product could be dangerous for fish and aquatic organisms.
therapeutic activity is reduced in the presence of piperonyl butoxide. The concomitant
use of these substances with amitraz should be avoided.
Do not use any other parasiticide veterinary medicinal product at the same time.
Store in the original package.
Keep the package tightly closed.
Protect from light.
Do not use during honey flow.
Do not extract honey from the brood chamber.
Do not harvest honey when the treatment is in place.
AN: 01357/2024 & 01394/2024Page 5 of 6
Brood combs should be replaced with new foundation at least every three years. Do
not recycle brood frames as honey frames.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Amitraz
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Apitraz 500 mg Bee-hive Strips for Honey Bees
AVM-GSLLaboratorios Calier, S.A.
Apitraz 500 mg Bee-hive Strips for Honey Bees
AVM-GSLLaboratorios Calier, SA
Apivar 500 mg Bee-hive Strips for Honey Bees
AVM-GSLVeto-Pharma SAS
Optivar 500 mg Beehive Strips for Honey Bees
AVM-GSLVeto-Pharma SAS
Optivar 500 mg Beehive Strips for Honey Bees
AVM-GSLVeto-Pharma SAS
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