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POM-V Prescription Required Companion Animal

Xeden 50 mg Tablet for Dogs

Active ingredient: Enrofloxacin

Form

Tablet

Species

Dogs

Manufacturer

Ceva Animal Health Ltd

VMD MA No.

15052/5092

What it's used for

- Treatment of superficial and deep pyoderma.

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Enrofloxacin

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Xeden 50 mg Tablet for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

- Treatment of superficial and deep pyoderma.
- 10 days in lower urinary tract infections
- 15 days in upper urinary tract infections and lower urinary tract infections
associated with prostatitis
- Up to 21 days in superficial pyoderma depending on clinical response
- Up to 49 days in deep pyoderma depending on clinical response
The treatment should be reconsidered in case of lack of clinical improvement at half
of the treatment duration.
Xeden 50 mg
Number of tablets per
day
Xeden 150 mg
Number of tablets per
day
Dogweight (kg)¼≥ 2-< 4 ½≥ 4-< 6.5¾¼≥ 6.5-< 8.5 1¼≥ 8.5-< 111 ¼½≥ 11-< 13.51 ½½ ≥-< 17 ¾≥ 17-< 25 1≥ 25-< 351 ¼≥ 35-< 401 ½≥ 40-< 501 ¾≥ 50-< 55 2≥ 55-< 65
To ensure a correct dosage body weight should be determined as accurately as
possible to avoid underdosing.
The tablets are flavoured, and are well accepted by dogs. The tablets may be
administered directly in the mouth of the dog or simultaneously with food if
necessary.
Instruction on how to divide the tablet: Put the tablet on an even surface, with its
scored side facing down (convex face up). With the tip of the forefinger, exert slight
vertical pressure on the middle of the tablet to break it along its width into halves.
Then, in order to obtain quarters, exert slight pressure on the middle of one half with
the forefinger to break it into two parts.
Do not use in young or growing dogs (dogs aged less than 12 months (small breed)
or less than 18 months (large breed)) as the product may cause epiphyseal cartilage
alterations in growing puppies.
Do not use in dogs having seizure disorders, since enrofloxacin may cause CNS
stimulation.
Do not use in dogs with known hypersensitivity to fluoroquinolones or to any of the
excipients of the product.
Do not use in case of resistance to quinolones, as there exists almost complete cross
resistance to other quinolones and complete cross resistance to other
fluoroquinolones.
See also section 3.7 and 3.8.
Dog:
Rare
(1 to 10 animals / 10,000
animals treated):
Vomiting
Anorexia
Hypersensitivity reaction
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Neurological signs (Ataxia, Tremor, Seizure,
Excitation)
Joint cartilage disorder
1
In this case, the administration of the product should be stopped.
Possible alterations in growing puppies.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
None

Special precautions for safe use in the target species:
Fluoroquinolones should be reserved for the treatment of clinical conditions which
have responded poorly, or are expected to respond poorly, to other classes of
antimicrobials.
Wherever possible, fluoroquinolones should be used based on susceptibility testing.
Use of the product deviating from instructions given in the SPC may increase the
prevalence of bacteria resistant to fluoroquinolones and may decrease the
effectiveness of treatment with other quinolones due to the potential for cross
resistance.
Official and local antimicrobial policies should be taken into account when the product
is used.
Use the product with caution in dogs with severe renal or hepatic impairment.
Pyoderma is mostly secondary to an underlying disease. It is advisable to determine
the underlying cause and to treat the animal accordingly.
The chewable tablets are flavoured. In order to avoid any accidental ingestion, store
tablets out of reach of the animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to (fluoro)quinolones should avoid contact with
the veterinary medicinal product. In case of accidental ingestion seek medical advice
immediately and show the package leaflet or the label to the physician. Wash hands
after handling the product. In case of contact with eyes, rinse immediately with plenty
of water.
Special precautions for the protection of the environment:
Not applicable.
Concurrent use of flunixin should be under careful veterinary monitoring, as the
interactions between these drugs may lead to adverse events related to delayed
elimination.
Concomitant administration of theophylline requires careful monitoring as serum
levels of theophylline may increase.
Concurrent use of magnesium or aluminum containing substances (such as antacids
or sucralfate) may reduce absorption of enrofloxacin. These drugs should be
administered two hours apart.
Do not use with tetracyclines, phenicols or macrolides because of potential
antagonistic effects.
Store in the original container. Protect from light.
This medicinal product does not require any special temperature storage conditions.
Any divided tablets should be returned to the original blister for storage.
Any divided tablets remaining after 3 days should be discarded.
Not applicable

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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