Vimectanin DUO 50 mg/ml + 1 mg/ml Oral Suspension for Sheep

Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of infection based on its epidemiological features,
for each herd.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd,
maintenance of susceptible refugia is essential to reduce that risk. Systematically
applied interval-based treatment and treatment of a whole herd should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry
and pasture management measures. Guidance for each specific herd should be
sought from the responsible veterinarian.
In the absence of risk of co-infection of nematodes, trematodes and nasal bots, a
narrow spectrum product should be used.
In sheep, resistance to ivermectin is widespread in Teladorsagia circumcincta,
Trichostrongylus spp., Haemonchus contortus and in other gastro-intestinal parasite
species.
Multiple resistance was reported in Teladorsagia circumcincta
macrocyclic lactones and levamisole and in Haemonchus contortus to ivermectin
and benzimidazoles.
Resistance to triclabendazole has been reported in Fasciola hepatica in sheep.
The use of this product should take into account local information about susceptibility
of the target parasites, where available.
It is recommended to further investigate cases of suspected resistance, using an
appropriate diagnostic method (e.g. Faecal Egg Count Reduction test, FECR test).
Confirmed resistance should be reported to the marketing authorisation holder or to
the competent authorities.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
The veterinary medicinal product may cause hypersensitivity (allergic reactions).
People with known hypersensitivity to the active substances or to any of the excipients
should avoid contact with the veterinary medicinal product.
This veterinary medicinal product may cause skin and eye irritation.
Direct contact with the skin should be kept to a minimum. Personal protective
equipment consisting of gloves should be worn when handling the veterinary medicinal
product.
In case of accidental spillage onto skin or into the eyes, wash immediately with plenty
of water. Take off any contaminated clothes.
Do not eat, drink or smoke whilst handling the veterinary medicinal product. Wash
hands thoroughly after use.
Special precautions for the protection of the environment:
Ivermectin is highly toxic to aquatic organisms, and ivermectin and triclabendazole
are highly toxic to dung flies and beetles. Long-term effects on dung insects caused
by continuous or repeated use cannot be excluded.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too
frequent and repeated use of this product and other products of the same
anthelmintic class in cattle, sheep and pigs. Therefore repeated treatment of
animals on a pasture with an ivermectin-containing product within a season should
only be given in the absence of alternative treatments or approaches to maintain
animal/flock health, as advised by a veterinarian.
Other precautions:
Extra-label use in dogs should be avoided as severe adverse reactions may occur.
Certain breeds of dogs, such as Collies, their related breeds and their mixes are
especially sensitive to ivermectin and particular care should be taken to avoid
accidental consumption of the product.