Versican Plus Pi Lyophilisate and Solvent for Suspension for Injection for Dogs

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product other than Versiguard Rabies and Versican
Plus L4. A decision to use this vaccine before or after any other veterinary medicinal
product therefore needs to be made on a case by case basis.

Unlimited Renewal: May 2024
AN: 03953/2023
Leptospira:
If protection against is required, dogs can be vaccinated with two doses
of Versican Plus Pi mixed with Versican Plus L4 3–4 weeks apart from 6 weeks of
age:
The contents of a single vial of Versican Plus Pi should be reconstituted with the
contents of a single vial of Versican Plus L4 (instead of the solvent). Once mixed, the
contents of the vial should appear a whitish to yellowish colour with light
opalescence. The mixed vaccines should be injected immediately via the
subcutaneous route.
Rabies:
If protection against rabies is required:
First dose: Versican Plus Pi from 8–9 weeks of age.
Second dose: Versican Plus Pi mixed with Versiguard Rabies 3–4 weeks later, but
not before 12 weeks of age.
The contents of a single vial of Versican Plus Pi should be reconstituted with the
contents of a single vial of Versiguard Rabies (instead of the solvent). Once mixed,
the contents of the vial should appear a pink/red or yellowish colour with light
opalescence. The mixed vaccines should be injected immediately via the
subcutaneous route.
The efficacy of the rabies fraction is proven after a single dose from 12 weeks of age
in laboratory studies. However, in field studies 10% of seronegative dogs did not
show seroconversion (>0.1IU/ml) 3–4 weeks after single primary vaccination against
rabies. Some animals may also not show titres > 0.5 IU/ml after the primary
vaccination. Antibody titres drop over the course of the 3-year duration of immunity,
although dogs are protected when challenged. In case of travelling to risk areas or
outside the UK, veterinary surgeons may wish to give additional rabies vaccinations
after 12 weeks of age to ensure that the vaccinated dogs have an antibody titre of
≥ 0.5 IU/ml, which is generally regarded as sufficiently protective and that they meet
the travel test requirements (antibody titres ≥ 0.5 IU/ml).
Although the efficacy of the rabies fraction has been demonstrated following
administration at 12 weeks, at the discretion of the veterinary surgeon, in case of
need, dogs younger than 8 weeks can be vaccinated with Versican Plus Pi mixed
with Versiguard Rabies as the safety of this association has been demonstrated in 6-
week old dogs.

Unlimited Renewal: May 2024
AN: 03953/2023