Canigen Pi Lyophilisate and Solvent for Suspension for Injection for Dogs

Safety and efficacy data (viral excretion) are available which demonstrate that this
vaccine can be mixed and administered with the inactivated vaccines of the Canigen

Revised: November 2024
AN: 01815/2024
range against canine leptospirosis caused by all or some of the following serovars:
L. interrogans serogroup Canicola serovar Canicola, . interrogans serogroup
Icterohaemorrhagiae serovar Copenhageni, . interrogans serogroup Australis
serovar Bratislava, and . serogroup Grippotyphosa serovar
Bananal/Liangguang.
The product information of the relevant Canigen vaccines should be consulted before
administration of the mixed product. When mixed with Canigen leptospirosis vaccines
at annual revaccination, it has been established that there is no interference with the
anamnestic response induced by the injectable canine parainfluenza virus
component.
After administration with one of the leptospirosis vaccines, a mild and transient
increase in body temperature 1°C) may occur for a few days after vaccination, with
some pups showing less activity and/or a reduced appetite. A small transient swelling
(≤ 4 cm), which can occasionally be firm and painful on palpation, may be observed
at the site of injection. Any such swelling will either have disappeared or be clearly
diminished by 14 days post-vaccination.
After mixed administration of an overdose of Canigen Pi and an overdose of the
leptospirosis vaccines in the Canigen range, transient local reactions such as diffuse
to firm swellings from 1 to 5 cm in diameter may be observed, usually these will
persist no longer than 5 weeks, however some may take a little longer to completely
disappear.
Safety and efficacy data are available which demonstrate that this vaccine can be
mixed and administered with the inactivated vaccine in the Canigen range against
rabies or the inactivated vaccine against rabies and leptospirosis, where applicable.
After administration with the rabies containing vaccines transient local reactions such
as diffuse to firm swellings from 1 to 4 cm in diameter may be observed for up to 3
weeks after vaccination. The swellings may be painful for up to 3 days post dosing.
Safety data are available which demonstrate that this vaccine can be administered at
the same time but not mixed with the inactivated vaccine in the Canigen range
against .
When this vaccine is administered in association with the inactivated vaccine in the
Canigen range against , the demonstrated antibody
response data of this vaccine are the same as when this vaccine is administered
alone.
When Canigen Pi is used with any of the other Canigen vaccines referred to above,
the minimum vaccination age for each vaccine must be taken into account such that
at the time of vaccination, the dogs are at or older than the oldest minimum
vaccination age for the individual vaccines.
No information is available on the compatibility of this vaccine when used with any
other veterinary medicinal product except the products mentioned above. A decision
to use this vaccine before or after any other veterinary medicinal product therefore
needs to be made on a case by case basis.

Revised: November 2024
AN: 01815/2024