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NFA-VPS Over the Counter Companion Animal

Vectra Felis 423 mg/42.3 mg Spot-on Solution for Cats

Active ingredients: Dinotefuran, Pyriproxyfen

Form

Spot-on

Species

Cats

Manufacturer

Ceva Animal Health Ltd

VMD MA No.

15052/5025

What it's used for

Treatment and prevention of flea infestations (Ctenocephalides felis) on cats. One application prevents flea infestation for one month. It also prevents th...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Dinotefuran + Pyriproxyfen

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Vectra Felis 423 mg/42.3 mg Spot-on Solution for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Treatment and prevention of flea infestations (Ctenocephalides felis) on cats.
One application prevents flea infestation for one month. It also prevents the
multiplication of fleas by inhibiting flea emergence in the environment of the cat for 3
months.
Dosage:
The minimum recommended dose is 42.3 mg dinotefuran/kg bodyweight and 4.23
mg pyriproxyfen/kg bodyweight.
The treatment dose range is 42.3 to 705 mg dinotefuran/kg bodyweight (bw) and
4.23 to 70.5 mg pyriproxyfen/kg bodyweight (bw) for cats of 0.6 kg to 10 kg
bodyweight.
Method and route of administration:
Spot-on use.
Care should be taken to apply the veterinary medicinal product only onto intact
(undamaged) cat’s skin.
Treatment schedule:
Following a single administration, the veterinary medicinal product will prevent flea
infestation for one month and prevent further flea multiplication by inhibiting flea
emergence in the environment of the cat for 3 months. The need to re-treat cats
which are likely to be re-infested, and the time interval between such treatments,
should be based on an assessment by a veterinarian.
How to apply:
Remove the spot-on applicator from the pack.
Step 1: Hold the applicator upright, placing fingers below the larger disk as shown.
Step 2: With the other hand, press downwards on the smaller disk until the 2 disks
meet evenly. This will pierce the seal.

Revised: October 2022
AN: 01764/2022
Step 3: The cat should be standing or in a comfortable position for easy application.
At the base of cat’s head, part the hair until the skin is visible. Apply the veterinary
medicinal product slowly with the tip of the applicator on the skin. Avoid superficial
application to the cat’s hair.
Do not use in cats or kittens weighing less than 0.6 kg.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.

Revised: October 2022
AN: 01764/2022
Slight scales, transient erythema and alopecia can be observed in rare cases, which
usually disappear spontaneously without treatment.
Transient neurological signs such as muscle tremors or lethargy may occur very
rarely and in particular after application site licking.
Transient cosmetic effects such as wet hair and a white dry residue may occur at the
application site very rarely and may persist up to 7 days; however, these effects are
usually not noticeable after 48 hours. These changes do not affect the safety or the
efficacy of the veterinary medicinal product.
Other application site disorders such as erythema, pruritus, lesions and inflammation
may occur very rarely.
Hyperactivity and tachypnoea may occur very rarely.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
All cats within the household should be treated. Dogs in the household should only
be treated with a veterinary medicinal product authorised for use in that species.
Fleas can infest the cat’s basket, bedding and regular resting areas such as carpets
and soft furnishings. In case of massive flea infestation and at the beginning of the
control measures, these areas should be treated with a suitable insecticide and then
vacuumed regularly.
The impact of shampooing on the efficacy of the veterinary medicinal product has not
been evaluated.
In case of suspicion of dermatitis (itch and skin irritation), seek for veterinary advice.

Special precautions for use in animals
The safety of the product has not been established in cats younger than 7 weeks or
weighing less than 0.6 kg (see section 4.3).
After accidental ingestion of the product, transient reactions such as salivation,
abnormal faeces and emesis may occur, however these should resolve without
treatment within 4 hours.
Care should be taken to apply the dose to an area where the animal cannot lick it off
(see section 4.9), and to ensure that animals do not groom each other immediately
following treatment.
Care should be taken to ensure that the contents of the spot-on applicator, or the
applied dose, do not come into contact with the eyes of the cat to be treated and/or
any other animals.
No studies have been performed in sick or convalescent cats, therefore use in these
cats should be based on the benefit-risk assessment of a veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to dinotefuran, pyriproxyfen or dimethyl sulfoxide
should avoid contact with this veterinary medicinal product.
The veterinary medicinal product is irritating to the eyes and skin.
To avoid adverse reactions:
•
•
•
water.

Revised: October 2022
AN: 01764/2022
•
rinsed with water immediately, with the eyelids open, and for a sufficient length of
time.
•
the product. It is therefore recommended to treat the animal in the evening.
•
children, on the day of treatment.
•
or reach of children.
If skin or if eye irritation persists, or in case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
None known.

Revised: October 2022
AN: 01764/2022
This veterinary medicinal product does not require any special storage conditions.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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