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NFA-VPS Over the Counter Companion Animal

Vectra 3D Spot-on Solution for Dogs 25–40 kg

Active ingredients: Dinotefuran, Permethrin (Cis:Trans 40:60), Pyriproxyfen

Form

Spot-on

Species

Dogs

Manufacturer

Ceva Animal Health Ltd

VMD MA No.

15052/5023

What it's used for

Ticks: The veterinary medicinal product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ric...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Clinical information

Vectra 3D Spot-on Solution for Dogs 25–40 kg — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Ticks:
The veterinary medicinal product has persistent acaricidal and repellent efficacy against
tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for one month, and
Dermacentor reticulatus for up to three weeks)
If ticks are present when the veterinary medicinal product is applied, the ticks may not all
be killed within the first 48 hours, but they may be killed within a week. To remove ticks, it
is recommended to use an appropriate tick removal device.
Sand flies, mosquitoes and stable flies:
The treatment provides persistent repellent (anti-feeding) activity. It prevents biting from
sand flies (Phlebotomus perniciosus), mosquitoes (Culex pipiens, Aedes aegypti) and from
stable flies (Stomoxys calcitrans) for one month post-application. The treatment also
provides persistent insecticidal activity for one month against mosquitoes (Aedes aegypti)
and stable flies (Stomoxys calcitrans).
pyriproxyfen/kg body weight and 46.6 mg permethrin/kg body weight, equivalent to 0.12 ml
of the veterinary medicinal product per kg body weight.
The following table shows the size of spot-on applicator to be used according to the weight
of the dog:
Weight of dog
(kg)
Colour of
applicator
cap
Volume
(ml)
Applicator to be used
> 25-40 kgPurple4.7Vectra 3D for dogs > 25-40 kg
Method and route of administration
Spot-on use. 1 applicator per dog.
Care should be taken to apply the veterinary medicinal product only onto intact
(undamaged) dog's skin.
How to apply:
Remove the spot-on applicator from the pack.
Step 1: Hold the applicator upright, placing fingers below the larger disk as shown.
Step 2: With the other hand, press downwards on the smaller disk until the 2 disks meet
evenly. This will pierce the seal.
Step 3: The dog should be standing or in a comfortable position for easy application. Part
the hair until the skin is visible. Apply the veterinary medicinal product (as directed in step
4 below) slowly with the tip of the applicator on the skin.
Step 4: Use according to 4a or 4b recommendation.
4a recommendation: Gently squeeze the applicator and apply the veterinary medicinal
product to the skin along the dog's back, beginning between the shoulder blades, in the
number of spots and order shown in the diagrams below and squeezing until the applicator
is empty. Avoid superficial application to the dog’s hair. The number of application spots
will depend on the body weight of the dog.
Dogs over 10 kg and up to 40 kg body
weight1 blue or purple pipette per dog to be
split in 3 spots
OR
4b recommendation: Regardless of the dog’s body weight, using the
applicator tip, part the hair at the base of the tail and begin applying the
veterinary medicinal product directly onto the skin in a continuous line
from the base of the tail along the centre of the back all the way up to
the shoulder blades, as shown in the diagram, squeezing the applicator
until it is empty.
Treatment schedule:
Following a single administration, the veterinary medicinal product will prevent infestation
for one month. The treatment can be repeated once a month.
Do not use in cases of hypersensitivity to any of the active substances or to any of the
excipients.
Do not use on cats. Due to their unique physiology and inability to metabolise permethrin,
this veterinary medicinal product must not be used on cats. If applied to a cat, or ingested
by a cat that actively grooms a recently treated dog, this veterinary medicinal product may
have serious harmful effects. (See section 3.5.)
Dogs:
Rare
(1 to 10 animals / 10,000 animals
treated):
Application site reaction
(e.g. Erythema, Pruritus)
Discomfort
1,2
Behavioural disorder (e.g. Hyperactivity,
Vocalisation, Anxiety)
Neurological disorder (e.g. Muscle tremor)
Systemic disorder (e.g. Lethargy, Anorexia)
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Application site reaction
(e.g. Hair change (wet
appearance, spiking), Residue)
Digestive tract disorder (e.g. Vomiting, Diarrhoea)
Ataxia

(e.g. Unsteady movement)
Convulsion
Mild and transient. If signs persist or worsen, veterinary advice should be sought.
At the application site.
Transient, these signs are usually not noticeable after 48 hours.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
All dogs within the household should be treated. Cats in the household should only be
treated with a veterinary medicinal product authorised for use in that species.
Fleas can infest the dog’s basket, bedding and regular resting areas such as carpets and
soft furnishings. In case of massive flea infestation and at the beginning of the control
measures, these areas should be treated with a suitable insecticide and then vacuumed
regularly.
The veterinary medicinal product remains effective when treated animals are immersed in
water (e.g. swimming, bathing). Water immersion repeated weekly for one month and
starting 48 hours after treatment, as well as shampooing 2 weeks after treatment do not
affect the efficacy of this product. However, in case of frequent shampooing, or bathing
within 48 hours after treatment, the duration of activity may be reduced.

Special precautions for safe use in the target species:
This veterinary medicinal product can induce convulsions in cats that could be fatal, due to
the unique physiology of this species which is unable to metabolise certain compounds,
including permethrin. In case of accidental exposure, if undesirable effects occur, wash the
cat with shampoo or soap. To prevent cats from being accidentally exposed to the
veterinary medicinal product, keep cats away from treated dogs until the application site is
dry. It is important to ensure that cats do not groom the site of application on a dog which
has been treated with this veterinary medicinal product.
In case of suspicion of dermatitis (itch and skin irritation), seek veterinary advice.
The safety of the veterinary medicinal product has not been established in dogs younger
than 7 weeks or weighing less than 1.5 kg.
Care should be taken to avoid contact between the veterinary medicinal product and the
eyes of the dog. If in eyes, immediately flush with water.
The attachment of a single tick after treatment cannot be excluded. For this reason the
transmission of infectious diseases cannot be completely excluded if conditions are
favourable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Do not eat, drink or smoke while handling the veterinary medicinal product.
People with known hypersensitivity to any of the ingredients should avoid contact with the
veterinary medicinal product.
Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown
evidence of foetotoxic effects. The veterinary medicinal product should not be
administered by pregnant women and women suspected of being pregnant.
Personal protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product by women of childbearing age.
This veterinary medicinal product is irritating to the eyes and skin.
To avoid adverse reactions:
•
•
•
•
thoroughly flushed with water.
•
veterinary medicinal product. It is therefore recommended to treat dogs in the evening,
or before taking them for a walk.
•
owners, especially children.
•
reach of children.
If skin or eye irritation persists, or if the veterinary medicinal product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the label to
the physician.
Other precautions
Wait for the application site to dry before allowing the treated dog to come in contact with
fabrics or furnishings.
Special precautions for the protection of the environment
Treated dogs should not be allowed to enter surface water for 48 hours after treatment to
avoid adverse effects on aquatic organisms. (See section 5.5)
None known.
This veterinary medicinal product does not require any special storage conditions.
Not applicable

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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