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POM-V Prescription Required Companion Animal

Vanguard Lepto ci

Active ingredients: Leptospira canicola, Leptospira icterohaemorrhagiae

Form

Injection

Species

Dogs

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5181

What it's used for

Active immunisation of dogs to reduce clinical signs caused by and Leptospira icterohaemorrhagiae. Onset of immunity occurs by approximately two weeks afte...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

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    Fill it at a registered online retailer

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Prescription required

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Clinical information

Vanguard Lepto ci — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Active immunisation of dogs to reduce clinical signs caused by
and Leptospira icterohaemorrhagiae.
Onset of immunity occurs by approximately two weeks after the last dose of the
Basic Vaccination Scheme.
The duration of immunity is at least 12 months.
Dosage and route of administration:
Shake well and immediately inject the entire contents of the vial (1 ml)
subcutaneously. Do not use chemically sterilised syringes or needles, as these will
interfere with the effectiveness of the vaccine.
Use with Vanguard R
To mix both products, one vial of Vanguard Lepto ci should be mixed with 1 ml of
Vanguard R either in the Vanguard R vial or the syringe. Vanguard R will be well
shaken before use. The mixed vaccines will be gently shaken and then
administered immediately.
Basic Vaccination Scheme:
Puppies younger than 10 weeks of age
Two doses of Vanguard Lepto ci at least 14 days apart. The first dose can be
given as young as 7 weeks of age. The second dose should not be given until at
least 10 weeks of age.
Puppies 10 weeks of age and older
Two doses of Vanguard Lepto ci at least 14 days apart.
Re-vaccination Scheme:
A single dose of Vanguard Lepto ci to be given annually thereafter.
Do not use in unhealthy animals.
On very rare occasions, vaccinated dogs may have a transient swelling (up to 3
cm) 4-6 hours after vaccination which resolves after approximately 7 days.
Very rarely, if a systemic anaphylactic reaction occurs (eg vomiting,) administer
appropriate symptomatic treatment (e.g. adrenaline or an equivalent).
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during the
course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)
None.

Revised: January 2025
AN: 02727/2024

Special precautions for use in animals
Not applicable
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Safety and efficacy data are available which demonstrate that this vaccine can be
mixed and administered with veterinary medicinal products from the Vanguard
range containing canine distemper virus, canine parvovirus, canine adenovirus or
canine parainfluenza virus or Vanguard R (where authorised) or administered on
the same day at different injection sites.
After concurrent or mixed administration of Vanguard Lepto ci and Vanguard R,
vaccinated dogs may have a transient swelling (up to 6 cm) and a transient
swelling of the sub-mandibular and/or pre-scapular lymph nodes at the injection
site 4 hours after vaccination which resolve within 24 hours
No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product except the products mentioned above.
A decision to use this vaccine before or after any other veterinary medicinal
product therefore needs to be made on a case by case basis.

Revised: January 2025
AN: 02727/2024
Store and transport refrigerated (2°C – 8°C). Do not freeze.
Not applicable.
5. IMMUNOLOGICAL PROPERTIES
The vaccine is intended for the active immunisation of healthy puppies and dogs
against diseases caused by
icterohaemorrhagiae.
ATC VET QI07AB01

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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