Valemas 50 mg/ml Solution for Injection for Cattle, Sheep, Goats, Pigs, Dogs and Cats
Active ingredient: Enrofloxacin
Form
Injection
Species
Manufacturer
Fatro S.p.A.
VMD MA No.
11557/4003
What it's used for
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible strains of Escherichia coli. Treatment of septicaemia caused by enroflox...
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Valemas 50 mg/ml Solution for Injection for Cattle, Sheep, Goats, Pigs, Dogs and Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
coli.
Treatment of acute mycoplasma-associated arthritis due to enrofloxacin susceptible
strains of Mycoplasma bovis.
Sheep
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible
strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
coli.
Unlimited Renewal: September 2023
Treatment of mastitis caused by enrofloxacin susceptible strains of
aureus Escherichia coli.
Goats
Treatment of infections of the respiratory tract caused by enrofloxacin susceptible
strains of Pasteurella multocida Mannheimia haemolytica
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible
strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
coli
Treatment of mastitis caused by enrofloxacin susceptible strains of
aureus Escherichia coli.
Pigs
Treatment of infections of the respiratory tract caused by enrofloxacin susceptible
strains of ,
pleuropneumoniae.
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible
strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
coli.
Dogs
Treatment of infections of the alimentary, respiratory and urogenital tracts (including
prostatitis, adjunctive antibiotic therapy for pyometra), skin and wound infections, otitis
(externa/media) caused by enrofloxacin susceptible strains of
Escherichia coli, pp., pp.,
and Proteus spp.
Cats
Treatment of infections of the alimentary, respiratory and urogenital tracts (as
adjunctive antibiotic therapy for pyometra), skin and wound infections, caused by
enrofloxacin susceptible strains of, e.g.: ,
Pasteurella
fluoroquinolones or to any of the excipients.
Do not use in animals that are epileptic or suffer from seizures since enrofloxacin may
cause CNS stimulation.
Do not use in young dogs during their growth, i.e. in small breeds of dogs less than 8
months of age, in big breeds of dogs less than 12 months of age, in giant breeds of
dogs less than 18 months of age.
Do not use in cats less than 8 weeks of age.
Do not use in growing horses because of possible deleterious damage on articular
cartilage.
are generally mild and transient.
Local reactions at injection site
In calves, transient local tissue reactions may occur in very rare cases and may be
observed up to 14 days.
Unlimited Renewal: September 2023
In pigs, after intramuscular administration of the product, inflammatory reactions may
occur. They may persist up to 28 days after the injection.
In dogs, a moderate and transient local reaction (such as oedema) may occur.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s));
- common (more than 1 but less than 10 animals in 100 animals treated);
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated);
- rare (more than 1 but less than 10 animals in 10,000 animals treated);
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Unlimited Renewal: September 2023
Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the product
is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible fluoroquinolones should only be used based on susceptibility
testing.
Use of the product including use deviating from the instructions given in the SPC may
increase the prevalence of bacteria resistant to enrofloxacin and may decrease the
effectiveness of treatment with all fluoroquinolones due to the potential for cross-
resistance.
Special caution should be taken when using enrofloxacin in animals with impaired renal
function.
Special caution should be taken when using enrofloxacin in cats because higher doses
than recommended can cause retinal damage and blindness (see section 4.10).
Degenerative changes of articular cartilage were observed in calves treated orally with
30 mg enrofloxacin/kg body weight during 14 days.
The use of enrofloxacin in growing lambs at the recommended dose for 15 days
caused histological changes in the articular cartilage, not associated to clinical signs.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to (fluoro) quinolones should avoid any contact with
the product.
Valemas may cause skin and eye irritation. Avoid skin and eye contact. Wash any
splashes from skin or eyes immediately with water.
Do not eat, drink or smoke whilst handling the product.
Care should be taken to avoid accidental self-injection. In case of accidental self-
injection seek medical advice immediately and show the package leaflet or label to the
physician
Wash hands after use.
Other precautions
In countries where feeding of fallen stock to scavenger bird populations is permitted as
a conservation measure (see Commission Decision 2003/322/EC), the possible risk to
hatching success should be considered before feeding carcasses of livestock recently
treated with this product.
antagonistically to quinolones (e.g. macrolides, tetracyclines or phenicols).
Do not use concurrently with theophylline as the elimination of theophylline may be
delayed.
Care should be taken during the concomitant use of flunixin and enrofloxacin in dogs
to avoid adverse drug reactions. The decrease in drug clearances as a result of co-
administration of flunixin and enrofloxacin indicates that these substances interact
during the elimination phase. Thus, in dogs, the co-administration of enrofloxacin and
flunixin increased the AUC and the elimination half-life of flunixin and increased the
elimination half-life and reduced the Cmax of enrofloxacin.
Official and local antimicrobial policies should be taken into account when the product
is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible fluoroquinolones should only be used based on susceptibility
testing.
Use of the product including use deviating from the instructions given in the SPC may
increase the prevalence of bacteria resistant to enrofloxacin and may decrease the
effectiveness of treatment with all fluoroquinolones due to the potential for cross-
resistance.
Special caution should be taken when using enrofloxacin in animals with impaired renal
function.
Special caution should be taken when using enrofloxacin in cats because higher doses
than recommended can cause retinal damage and blindness (see section 4.10).
Degenerative changes of articular cartilage were observed in calves treated orally with
30 mg enrofloxacin/kg body weight during 14 days.
The use of enrofloxacin in growing lambs at the recommended dose for 15 days
caused histological changes in the articular cartilage, not associated to clinical signs.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to (fluoro) quinolones should avoid any contact with
the product.
Valemas may cause skin and eye irritation. Avoid skin and eye contact. Wash any
splashes from skin or eyes immediately with water.
Do not eat, drink or smoke whilst handling the product.
Care should be taken to avoid accidental self-injection. In case of accidental self-
injection seek medical advice immediately and show the package leaflet or label to the
physician
Wash hands after use.
Other precautions
In countries where feeding of fallen stock to scavenger bird populations is permitted as
a conservation measure (see Commission Decision 2003/322/EC), the possible risk to
hatching success should be considered before feeding carcasses of livestock recently
treated with this product.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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