Triclacert Duo 50 mg/ml & 1 mg/ml Oral Suspension for Sheep

Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class,
over an extended period of time.
• Underdosing which may be due to underestimation of bodyweight,
misadministration of the product or lack of calibration of the dosing
device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Resistance to ivermectin has been reported in Teladorsagia (Ostertagia)
circumcincta,Haemonchus contortus Trichostrongylus species in sheep, and
increasing resistance to triclabendazole has been reported in Fasciola species in
sheep in a number of countries including in Europe.
Therefore, the use of this product should be based upon local (regional, farm)
epidemiological information about susceptibility of the target parasites and
recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for safe use in the target species:
Extra-label use in dogs should be avoided as severe adverse reactions may occur. In
common with other avermectins, certain breeds of dogs, such as Collies are
especially sensitive to ivermectin and particular care should be taken to avoid
accidental consumption of the product.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
• This product may cause hypersensitivity (allergic) reactions. People with
known hypersensitivity to ivermectin, triclabendazole or parabens should
avoid contact with the product.
• This product may cause skin and eye irritation.
• Avoid direct contact with the skin and eyes.
• Protective gloves should be worn when handling the product.
• In case of accidental spillage onto skin or into the eyes wash immediately with
water. Take off any contaminated clothes.
• Do not eat, drink or smoke whilst handling the product.
• Wash hands and any exposed skin before meals and after work.

Special precautions for the protection of the environment:
Long-term effects on dung insects caused by continuous or repeated use cannot be
excluded. The risk to aquatic ecosystems and dung fauna can be reduced by
avoiding too frequent and repeated use of this product and other products of the
same anthelmintic class in cattle, sheep and pigs. Therefore, the repetition of
treatment in a pasture during a season should be performed only in the absence of
alternative treatment and on veterinary advice.