POM-V Prescription Required Companion Animal

Spasmium Comp. 500 mg/ml + 4 mg/ml Solution for Injection

Active ingredients: Hyoscine Butylbromide, Metamizole sodium monohydrate

Form

Injection

Species

Cattle Dogs Horses Pigs

Manufacturer

VetViva Richter GmbH

VMD MA No.

57446/5008

What it's used for

Horses: Spasmodic colics. Cattle, pigs, dogs: As supportive therapy for acute diarrhoea.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Prescription required

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Clinical information

Spasmium Comp. 500 mg/ml + 4 mg/ml Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Horses:
Spasmodic colics.
Cattle, pigs, dogs:
As supportive therapy for acute diarrhoea.

Intramuscular use (i.m.): pigs, dogs
Dosage instruction:
Horses (i.v.): 25 mg metamizole sodium monohydrate/kg body weight and
0.2 mg hyoscine butylbromide/kg body weight (i.e. 2.5 ml per 50 kg)
Cattle (i.v.): 40 mg metamizole sodium monohydrate/kg body weight and
0.32 mg hyoscine butylbromide/kg body weight (i.e. 4 ml per 50 kg)
Calves (i.v.): 50 mg metamizole sodium monohydrate/kg body weight and
0.4 mg hyoscine butylbromide/kg body weight (i.e. 1 ml per 10 kg)
Pigs (i.m.): 50 mg metamizole sodium monohydrate/kg body weight and
0.4 mg hyoscine butylbromide/kg body weight (i.e. 1 ml per 10 kg)
Dogs (i.v. or i.m.):
0.4 mg hyoscine butylbromide/kg body weight (i.e. 0.1 ml per kg)
Treatment frequency:
Cattle and calves: up to twice daily for three days.
Horses and pigs: single injection.
Dogs: single injection. Treatment can be repeated after 24 hours if necessary.
The stopper must not be punctured more than 25 times.

Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Do not use in cases of:
- gastro-intestinal ulceration
- chronic gastro-intestinal disorders
- mechanic stenoses in the gastro-intestinal system
- paralytic ileus in horses
- disorders of the haematopoietic system
- coagulopathies
- renal insufficiency
- tachyarrhythmia
- glaucoma
- prostate adenoma.

Horses, cattle, pigs, dogs:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylactic-type reaction
Undetermined frequency
(cannot be estimated from the
available data):
Increased heart rate
;
Dry mucous membrane
;
Paralytic ileus
, Constipation
;
Urinary retention
;
Injection site pain
1
Should be treated symptomatically.
In horses and cattle. Slightly. Due to the parasympatholytic activity of hyoscine
butylbromide.
Based on pharmacological properties of hyoscine butylbromide.
In dogs. Can occur immediately after injection, which abate rapidly without negative
impact on the expected therapeutic benefit.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

None.

Special precautions for safe use in the target species:
Due to the risk of anaphylactic shock metamizole-containing solutions should be
administered slowly when given intravenously.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In a very small number of people, metamizole can cause reversible, but potentially
serious agranulocytosis and other reactions such as skin allergy. Take care to avoid
self-injection.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
People with known hypersensitivity to metamizole or hyoscine butylbromide should
avoid contact with the veterinary medicinal product. Avoid use of the veterinary
medicinal product if you are known to be sensitive to pyrazolones or are sensitive to
acetylsalicylic acid.
Wash splashes from skin and eyes immediately.
Special precautions for the protection of the environment:
Not applicable.

The effects of metamizole and/or hyoscine butylbromide may be potentiated by
concurrent use of other anticholinergic or analgesic substances.
Concomitant use of inducers of hepatic microsomal enzymes (e.g. barbiturates,
phenylbutazone) reduces the half-life period and hence the duration of action of
metamizole. Simultaneous administration of neuroleptics, especially phenothiazine
derivatives, may lead to severe hypothermia. Furthermore, the risk of gastro-
intestinal bleeding is increased upon concurrent use of glucocorticoids. The diuretic
effect of furosemide is attenuated.
Co-administration of other weak analgesics increases the effects and side-effects of
metamizole.
The anticholinergic action of chinidin and antihistaminics as well as the tachycardic
effects of β-sympathomimetics may be enhanced by this veterinary medicinal
product.

After first opening the immediate packaging do not store above 25°C.

Meat and offal:
Horses, cattle (i.v.)12 days
Pigs (i.m.) 15 days
Milk:
Cattle (i.v.) 96 hours
Not authorised for use in mares producing milk for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.